Is Dyadic International, Inc. overvalued or undervalued?

As of 27 March 2019, the valuation grade for Dyadic International, Inc. moved from does not qualify to risky, indicating a significant downgrade in its investment appeal. The company appears to be overvalued, particularly given its high Price to Book Value of 41.92 and negative EV to EBIT and EV to EBITDA ratios of -6.89, which suggest that the company is not generating positive earnings before interest and taxes or earnings before interest, taxes, depreciation, and amortization. Additionally, the negative ROE of -582.71% further underscores the company's financial struggles.
In comparison to its peers, Dyadic's P/E ratio is notably absent due to its loss-making status, while Nutex Health, Inc. presents a very attractive P/E of 3.08, highlighting a stark contrast in valuation metrics. Other risky peers like Personalis, Inc. and Sonida Senior Living, Inc. also show negative valuations, but with less extreme ratios than Dyadic. The stock's performance has been disappointing, with a year-to-date return of -43.91%, significantly underperforming the S&P 500's 12.22% return, and a staggering decline of -87.82% over the past five years, further reinforcing the notion that the stock is overvalued in its current state.