Is OpGen, Inc. overvalued or undervalued?

As of 30 March 2016, OpGen, Inc. has moved from a valuation grade of "does not qualify" to "risky." The company is currently considered overvalued. Key ratios include a Price to Book Value of 15.85, an EV to EBIT of -7.71, and an EV to Sales of 36.37.
In comparison to peers, OpGen's valuation metrics indicate significant challenges, particularly with BTC Digital Ltd. showing a more severe EV to EBITDA of 4.35 and LM Funding America, Inc. at 0.08. The company has also demonstrated poor performance with a Return on Capital Employed (ROCE) of -351.21% and a Return on Equity (ROE) of -659.91%. While OpGen has experienced a remarkable year-to-date return of 720.17%, this is juxtaposed against a backdrop of substantial long-term losses, suggesting that current valuations may not be sustainable.