Compare Prothena Corp. Plc with Similar Stocks
Dashboard
1
Poor Management Efficiency with a low ROE of 3.07%
- The company has been able to generate a Return on Equity (avg) of 3.07% signifying low profitability per unit of shareholders funds
2
Flat results in Dec 25
3
Risky -
4
Consistent Underperformance against the benchmark over the last 3 years
Stock DNA
Pharmaceuticals & Biotechnology
USD 494 Million (Micro Cap)
NA (Loss Making)
NA
0.00%
-1.09
-76.30%
1.76
Revenue and Profits:
Net Sales:
0 Million
(Quarterly Results - Dec 2025)
Net Profit:
-22 Million
Total Returns (Price + Dividend) 
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
-2.94%
0%
-2.94%
6 Months
-1.59%
0%
-1.59%
1 Year
-28.82%
0%
-28.82%
2 Years
-63.2%
0%
-63.2%
3 Years
-80.64%
0%
-80.64%
4 Years
-74.94%
0%
-74.94%
5 Years
-65.58%
0%
-65.58%
Prothena Corp. Plc for the last several years.
Risk Adjusted Returns v/s 
News
No Recent News for the Company
Announcements 
No announcement available
Corporate Actions 
No corporate action available
Quality key factors 
Factor
Value
Sales Growth (5y)
57.95%
EBIT Growth (5y)
-18.35%
EBIT to Interest (avg)
-111.73
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-0.95
Sales to Capital Employed (avg)
0.19
Tax Ratio
4.83%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
0
ROE (avg)
3.07%
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
1.76
EV to EBIT
-1.02
EV to EBITDA
-1.04
EV to Capital Employed
-7.82
EV to Sales
19.52
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
Negative Capital Employed
ROE (Latest)
-76.30%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Bearish
Mildly Bullish
RSI
No Signal
No Signal
Bollinger Bands
Mildly Bearish
Mildly Bearish
Moving Averages
Bullish (Daily)
KST
Bearish
Mildly Bullish
Dow Theory
Mildly Bearish
Mildly Bearish
OBV
Mildly Bearish
Mildly Bearish
Shareholding Snapshot : Dec 2025
Shareholding Compare (%holding) 
Majority shareholders
Domestic Funds
Domestic Funds
Held in 57 Schemes (48.12%)
Foreign Institutions
Held by 112 Foreign Institutions (11.16%)
Strategic Entities with highest holding
Highest Public shareholder
Quarterly Results Snapshot (Consolidated) - Dec'25 - QoQ
Dec'25
Sep'25
Change(%)
Net Sales
0.00
2.40
-100.00%
Operating Profit (PBDIT) excl Other Income
-26.30
-38.80
32.22%
Interest
0.00
0.00
Exceptional Items
3.00
-0.50
700.00%
Consolidate Net Profit
-21.60
-36.50
40.82%
Operating Profit Margin (Excl OI)
-1,295,761.90%
-16,464.20%
-1,27,929.77%
USD in Million.
Net Sales
QoQ Growth in quarter ended Dec 2025 is -100.00% vs -45.45% in Sep 2025
Consolidated Net Profit
QoQ Growth in quarter ended Dec 2025 is 40.82% vs 70.99% in Sep 2025
Annual Results Snapshot (Consolidated) - Dec'25
Dec'25
Dec'24
Change(%)
Net Sales
9.70
135.20
-92.83%
Operating Profit (PBDIT) excl Other Income
-180.90
-151.00
-19.80%
Interest
0.00
0.00
Exceptional Items
-30.10
0.00
Consolidate Net Profit
-244.10
-122.30
-99.59%
Operating Profit Margin (Excl OI)
-19,058.20%
-1,143.60%
-1,791.46%
USD in Million.
Net Sales
YoY Growth in year ended Dec 2025 is -92.83% vs 47.92% in Dec 2024
Consolidated Net Profit
YoY Growth in year ended Dec 2025 is -99.59% vs 16.80% in Dec 2024
About Prothena Corp. Plc 
Prothena Corp. Plc
Pharmaceuticals & Biotechnology
Prothena Corporation Public Limited Company is a global biotechnology company. The Company is focused on the discovery, development and commercialization of immunotherapies for the treatment of diseases that involve protein misfolding or cell adhesion. The Company's clinical pipeline of antibody-based product candidates targets a range of indications, including Amyloid Light-chain (AL) amyloidosis (NEOD001), Parkinson's disease and other related synucleinopathies (PRX002), and inflammatory diseases, including psoriasis and psoriatic arthritis (PRX003) and ATTR amyloidosis (PRX004). The Company has generated monoclonal antibodies that selectively bind to amyloidogenic (diseased) forms of the Transthyretin (TTR)-mediated amyloidosis (ATTR) protein. The Company's pipeline also includes late discovery-stage programs for which the Company is testing the efficacy of antibodies in preclinical models of diseases related to amyloid or cell adhesion.
Company Coordinates 
Company Details
Dublin 1, 25-28 North Wall Quay , DUBLIN None : A96 T927
Registrar Details






