Compare Prothena Corp. Plc with Similar Stocks
Dashboard
1
Poor Management Efficiency with a low ROE of 3.07%
- The company has been able to generate a Return on Equity (avg) of 3.07% signifying low profitability per unit of shareholders funds
2
Negative results in Jun 25
3
Risky - Negative EBITDA
4
Consistent Underperformance against the benchmark over the last 3 years
Stock DNA
Pharmaceuticals & Biotechnology
USD 521 Million (Micro Cap)
NA (Loss Making)
NA
0.00%
-1.11
-83.86%
1.77
Revenue and Profits:
Net Sales:
4 Million
(Quarterly Results - Jun 2025)
Net Profit:
-126 Million
Total Returns (Price + Dividend) 
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
2.56%
0%
2.56%
6 Months
47.93%
0%
47.93%
1 Year
-35.4%
0%
-35.4%
2 Years
-70.32%
0%
-70.32%
3 Years
-81.85%
0%
-81.85%
4 Years
-71.62%
0%
-71.62%
5 Years
-26.52%
0%
-26.52%
Prothena Corp. Plc for the last several years.
Risk Adjusted Returns v/s 
News
No Recent News for the Company
Announcements 
No announcement available
Corporate Actions 
No corporate action available
Quality key factors 
Factor
Value
Sales Growth (5y)
60.17%
EBIT Growth (5y)
-190.24%
EBIT to Interest (avg)
-111.73
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-0.95
Sales to Capital Employed (avg)
0.19
Tax Ratio
4.83%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
0
ROE (avg)
3.07%
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
0.67
EV to EBIT
0.90
EV to EBITDA
0.92
EV to Capital Employed
-5.55
EV to Sales
-0.90
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
Negative Capital Employed
ROE (Latest)
-25.19%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Mildly Bearish
Mildly Bullish
RSI
No Signal
No Signal
Bollinger Bands
Bullish
Mildly Bearish
Moving Averages
Bullish (Daily)
KST
Mildly Bearish
Mildly Bullish
Dow Theory
Mildly Bearish
Mildly Bearish
OBV
Mildly Bullish
Mildly Bearish
Shareholding Snapshot : Sep 2025
Shareholding Compare (%holding) 
Majority shareholders
Domestic Funds
Domestic Funds
Held in 59 Schemes (50.26%)
Foreign Institutions
Held by 107 Foreign Institutions (11.29%)
Strategic Entities with highest holding
Highest Public shareholder
Quarterly Results Snapshot (Consolidated) - Jun'25 - QoQ
Jun'25
Mar'25
Change(%)
Net Sales
4.40
2.80
57.14%
Operating Profit (PBDIT) excl Other Income
-51.10
-64.70
21.02%
Interest
0.00
0.00
Exceptional Items
-32.60
0.00
Consolidate Net Profit
-125.80
-60.20
-108.97%
Operating Profit Margin (Excl OI)
-11,766.30%
-23,189.90%
1,142.36%
USD in Million.
Net Sales
QoQ Growth in quarter ended Jun 2025 is 57.14% vs 33.33% in Mar 2025
Consolidated Net Profit
QoQ Growth in quarter ended Jun 2025 is -108.97% vs -3.79% in Mar 2025
Annual Results Snapshot (Consolidated) - Dec'24
Dec'24
Dec'23
Change(%)
Net Sales
135.20
91.40
47.92%
Operating Profit (PBDIT) excl Other Income
-151.00
-182.60
17.31%
Interest
0.00
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-122.30
-147.00
16.80%
Operating Profit Margin (Excl OI)
-1,143.60%
-2,090.80%
94.72%
USD in Million.
Net Sales
YoY Growth in year ended Dec 2024 is 47.92% vs 69.57% in Dec 2023
Consolidated Net Profit
YoY Growth in year ended Dec 2024 is 16.80% vs -25.75% in Dec 2023
About Prothena Corp. Plc 
Prothena Corp. Plc
Pharmaceuticals & Biotechnology
Prothena Corporation Public Limited Company is a global biotechnology company. The Company is focused on the discovery, development and commercialization of immunotherapies for the treatment of diseases that involve protein misfolding or cell adhesion. The Company's clinical pipeline of antibody-based product candidates targets a range of indications, including Amyloid Light-chain (AL) amyloidosis (NEOD001), Parkinson's disease and other related synucleinopathies (PRX002), and inflammatory diseases, including psoriasis and psoriatic arthritis (PRX003) and ATTR amyloidosis (PRX004). The Company has generated monoclonal antibodies that selectively bind to amyloidogenic (diseased) forms of the Transthyretin (TTR)-mediated amyloidosis (ATTR) protein. The Company's pipeline also includes late discovery-stage programs for which the Company is testing the efficacy of antibodies in preclinical models of diseases related to amyloid or cell adhesion.
Company Coordinates 
Company Details
Dublin 1, 25-28 North Wall Quay , DUBLIN None : A96 T927
Registrar Details






