Prothena Corp. Plc

  • Market Cap: Micro Cap
  • Industry: Pharmaceuticals & Biotechnology
  • ISIN: IE00B91XRN20
USD
11.16
0.81 (7.83%)
  • Price Points
  • Score
  • Mojo Parameters
  • Total Return
  • News and Corporate Actions
  • Key factors
  • Shareholding
  • Financials
  • CompanyCV
stock-summaryPrice Point
High/Low

1Day

52 Week

Valuation
Technical
Day's Volume

CASH

1.16 M

Shareholding (Mar 2025)

FII

10.93%

Held by 118 FIIs

DII

35.22%

Held by 57 DIIs

Promoter

4.48%

How big is Prothena Corp. Plc?

22-Jun-2025

As of Jun 18, Prothena Corp. Plc has a market capitalization of 306.81 million, with net sales of 137.93 million and a net profit of -110.27 million over the latest four quarters. The company reported shareholder's funds of 486.93 million and total assets of 547.11 million as of Dec 24.

Market Cap: As of Jun 18, Prothena Corp. Plc has a market capitalization of 306.81 million, categorizing it as a Micro Cap company.<BR><BR>Recent Quarterly Performance: For the latest four quarters, Prothena Corp. Plc reported net sales of 137.93 million and a net profit of -110.27 million.<BR><BR>Balance Sheet Snapshot: As of Dec 24, the company reported shareholder's funds of 486.93 million and total assets of 547.11 million.

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What does Prothena Corp. Plc do?

22-Jun-2025

Prothena Corp. Plc is a biotechnology company focused on developing immunotherapies for diseases related to protein misfolding and cell adhesion. As of March 2025, it has a market cap of $306.81 million, with net sales of $3 million and a net loss of $60 million.

Overview: <BR>Prothena Corp. Plc is a global biotechnology company focused on the discovery, development, and commercialization of immunotherapies for diseases involving protein misfolding or cell adhesion, operating within the Pharmaceuticals & Biotechnology industry and classified as a micro-cap company.<BR><BR>Financial Snapshot: <BR>Most recent Net Sales: 3 Million (Quarterly Results - Mar 2025) <BR>Most recent Net Profit: -60 Million (Quarterly Results - Mar 2025) <BR>Market cap: USD 306.81 Million (Micro Cap)<BR><BR>Key Metrics: <BR>P/E: NA (Loss Making) <BR>Industry P/E: NA <BR>Dividend Yield: 0.00% <BR>Debt Equity: -0.95 <BR>Return on Equity: -25.19% <BR>Price to Book: 0.70<BR><BR>Contact Details: <BR>Address: Dublin 1, 25-28 North Wall Quay, DUBLIN None : A96 T927 <BR>Tel: 353 1 2362500 <BR>Fax: 353 1 9023510 <BR>Website: http://www.prothena.com/

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Who are in the management team of Prothena Corp. Plc?

22-Jun-2025

As of March 2022, Prothena Corp. Plc's management team includes Dr. Lars Ekman (Independent Chairman), Dr. Gene Kinney (President and CEO), and several independent directors: Ms. Paula Cobb, Mr. Richard Collier, Mr. Shane Cooke, Dr. K. Anders Harfstrand, and Dr. Christopher Henney. The team features a blend of executive leadership and independent directors.

As of March 2022, the management team of Prothena Corp. Plc includes the following individuals:<BR><BR>- Dr. Lars Ekman, who serves as the Independent Chairman of the Board.<BR>- Dr. Gene Kinney, who is the President, Chief Executive Officer, and Director.<BR>- Ms. Paula Cobb, who is an Independent Director.<BR>- Mr. Richard Collier, who is also an Independent Director.<BR>- Mr. Shane Cooke, serving as an Independent Director.<BR>- Dr. K. Anders Harfstrand, who is an Independent Director.<BR>- Dr. Christopher Henney, who is an Independent Director.<BR><BR>In summary, the management team consists of a mix of independent directors and key executive leadership.

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Should I buy, sell or hold Prothena Corp. Plc?

22-Jun-2025

Is Prothena Corp. Plc overvalued or undervalued?

20-Sep-2025

As of August 8, 2022, Prothena Corp. Plc is considered overvalued and risky due to a negative return on equity of -25.19%, a price to book value ratio of 0.67, and unfavorable comparisons to peers, indicating a cautious outlook on its financial health.

As of 8 August 2022, Prothena Corp. Plc's valuation grade changed from fair to risky, indicating a shift towards a more cautious outlook. The company is currently overvalued based on its financial metrics, particularly given its negative return on equity of -25.19% and a price to book value ratio of 0.67, which suggests that the market is pricing the stock higher than its underlying assets justify. Additionally, the EV to EBITDA ratio stands at 0.92, reflecting a concerning valuation relative to its earnings potential.<BR><BR>In comparison to its peers, Prothena's valuation appears unfavorable; for instance, its peer has a P/E ratio of -1.69 and an EV to EBITDA of -0.36, highlighting a stark contrast in financial health. The absence of positive earnings further complicates the valuation picture, reinforcing the notion that the stock is overvalued. Although specific return data is not available, the lack of positive returns compared to the S&P 500 likely supports the view that the stock is not performing favorably in the market.

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Is Prothena Corp. Plc technically bullish or bearish?

07-Oct-2025

As of October 3, 2025, Prothena Corp. Plc shows a mildly bullish trend overall, supported by mixed technical indicators, including a bullish monthly RSI and weekly MACD, but tempered by bearish daily moving averages.

As of 3 October 2025, the technical trend for Prothena Corp. Plc has changed from sideways to mildly bullish. The weekly MACD is mildly bullish, while the monthly MACD also supports this stance. The monthly RSI is bullish, contrasting with the bearish weekly RSI. The Bollinger Bands indicate a mildly bullish trend on the weekly chart but are mildly bearish on the monthly. The KST shows a bullish weekly trend but a bearish monthly trend, and the Dow Theory indicates a mildly bullish monthly trend with no trend on the weekly. The daily moving averages are mildly bearish, which tempers the overall bullish sentiment. Overall, the indicators suggest a mildly bullish stance, albeit with some mixed signals, particularly in the short term. Multi-period return data is not available for comparison with the S&P 500.

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iScoreScore
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Strong Sell
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Strong Buy

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Dashboard
1

Poor Management Efficiency with a low ROE of 3.07%

  • The company has been able to generate a Return on Equity (avg) of 3.07% signifying low profitability per unit of shareholders funds
2

Negative results in Jun 25

3

Risky - Negative EBITDA

4

Consistent Underperformance against the benchmark over the last 3 years

stock-summaryMojo Parameters
Mojo Parameters
Stock DNA
stock-summary
Industry

Pharmaceuticals & Biotechnology

stock-summary
Market cap

USD 457 Million (Micro Cap)

stock-summary
P/E

NA (Loss Making)

stock-summary
Industry P/E

NA

stock-summary
Dividend Yield

0.00%

stock-summary
Debt Equity

-1.14

stock-summary
Return on Equity

-83.34%

stock-summary
Price to Book

1.41

Revenue and Profits:
Net Sales:
4 Million
(Quarterly Results - Jun 2025)
Net Profit:
-126 Million
stock-summaryTotal Returns
Total Returns (Price + Dividend) stock-summary
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
33.02%
0%
33.02%
6 Months
131.06%
0%
131.06%
1 Year
-19.01%
0%
-19.01%
2 Years
-68.01%
0%
-68.01%
3 Years
-82.83%
0%
-82.83%
4 Years
-76.05%
0%
-76.05%
5 Years
1.45%
0%
1.45%

Prothena Corp. Plc for the last several years.

Risk Adjusted Returns v/s stock-summary
stock-summaryNews & Corporate Actions
News
Announcements stock-summary
Icon
No announcement available
Corporate Actions stock-summary
Icon
No corporate action available
stock-summaryKey Factors
Quality key factors stock-summary
Factor
Value
Sales Growth (5y)
60.17%
EBIT Growth (5y)
-190.24%
EBIT to Interest (avg)
-111.73
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-0.95
Sales to Capital Employed (avg)
0.20
Tax Ratio
4.83%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
0
ROE (avg)
3.07%
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
0.67
EV to EBIT
0.90
EV to EBITDA
0.92
EV to Capital Employed
-5.55
EV to Sales
-0.90
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
Negative Capital Employed
ROE (Latest)
-25.19%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Bullish
Mildly Bullish
RSI
No Signal
No Signal
Bollinger Bands
Bullish
Bearish
Moving Averages
Bullish (Daily)
KST
Bullish
Mildly Bullish
Dow Theory
Mildly Bearish
No Trend
OBV
Mildly Bullish
Mildly Bullish
stock-summary Technical Indicator Scale: Bearish, Mildly Bearish, Sideways, Mildly Bullish, Bullish  Turned 
stock-summaryShareholding
Shareholding Snapshot : Mar 2025stock-summary
Shareholding Compare (%holding) stock-summary
Majority shareholders

Domestic Funds

Domestic Funds

Held in 69 Schemes (49.33%)

Foreign Institutions

Held by 118 Foreign Institutions (10.93%)

Strategic Entities with highest holding

Highest Public shareholder

stock-summaryFinancial
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  {
    "link": "quarterly",
    "btn_text": "All Quarterly Results",
    "header": "Quarterly Results Snapshot (Consolidated) - Jun'25 - QoQ",
    "rhs": [
      {
        "prefix": "Net Sales ",
        "suffix": "QoQ Growth in quarter ended Jun 2025 is 57.14% vs 33.33% in Mar 2025",
        "dir": 1
      },
      {
        "prefix": "Consolidated Net Profit ",
        "suffix": "QoQ Growth in quarter ended Jun 2025 is -108.97% vs -3.79% in Mar 2025",
        "dir": -1
      }
    ],
    "table": {
      "header": [
        "Jun'25",
        "Mar'25",
        "Change(%)"
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      "body": [
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          "field": "Net Sales",
          "val1": "4.40",
          "val2": "2.80",
          "chgp": "57.14%",
          "chgp_class": "positive"
        },
        {
          "field": "Operating Profit (PBDIT) excl Other Income",
          "val1": "-51.10",
          "val2": "-64.70",
          "chgp": "21.02%",
          "chgp_class": "positive"
        },
        {
          "field": "Interest",
          "val1": "0.00",
          "val2": "0.00",
          "chgp": "",
          "chgp_class": "neutral"
        },
        {
          "field": "Exceptional Items",
          "val1": "-32.60",
          "val2": "0.00",
          "chgp": "",
          "chgp_class": "neutral"
        },
        {
          "field": "Consolidate Net Profit",
          "val1": "-125.80",
          "val2": "-60.20",
          "chgp": "-108.97%",
          "chgp_class": "negative"
        },
        {
          "field": "Operating Profit Margin (Excl OI)",
          "val1": "-11,766.30%",
          "val2": "-23,189.90%",
          "chgp": "1,142.36%",
          "chgp_class": "positive"
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    "btn_text": "All Annual Results",
    "header": "Annual Results Snapshot (Consolidated) - Dec'24",
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        "dir": -1
      },
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        "prefix": "Consolidated Net Profit ",
        "suffix": "YoY Growth in year ended Dec 2024 is 16.80% vs -25.75% in Dec 2023",
        "dir": 1
      }
    ],
    "table": {
      "header": [
        "Dec'24",
        "Dec'23",
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          "field": "Net Sales",
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          "val2": "91.40",
          "chgp": "47.92%",
          "chgp_class": "positive"
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          "field": "Operating Profit (PBDIT) excl Other Income",
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          "val2": "-182.60",
          "chgp": "17.31%",
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          "field": "Interest",
          "val1": "0.00",
          "val2": "0.00",
          "chgp": "",
          "chgp_class": "neutral"
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          "field": "Exceptional Items",
          "val1": "0.00",
          "val2": "0.00",
          "chgp": "",
          "chgp_class": "neutral"
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          "field": "Consolidate Net Profit",
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          "val2": "-147.00",
          "chgp": "16.80%",
          "chgp_class": "positive"
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          "field": "Operating Profit Margin (Excl OI)",
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          "val2": "-2,090.80%",
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          "chgp_class": "positive"
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Quarterly Results Snapshot (Consolidated) - Jun'25 - QoQstock-summary
Jun'25
Mar'25
Change(%)
Net Sales
4.40
2.80
57.14%
Operating Profit (PBDIT) excl Other Income
-51.10
-64.70
21.02%
Interest
0.00
0.00
Exceptional Items
-32.60
0.00
Consolidate Net Profit
-125.80
-60.20
-108.97%
Operating Profit Margin (Excl OI)
-11,766.30%
-23,189.90%
1,142.36%
USD in Million.
Direction Arrows
Net Sales

QoQ Growth in quarter ended Jun 2025 is 57.14% vs 33.33% in Mar 2025

Direction Arrows
Consolidated Net Profit

QoQ Growth in quarter ended Jun 2025 is -108.97% vs -3.79% in Mar 2025

Annual Results Snapshot (Consolidated) - Dec'24stock-summary
Dec'24
Dec'23
Change(%)
Net Sales
135.20
91.40
47.92%
Operating Profit (PBDIT) excl Other Income
-151.00
-182.60
17.31%
Interest
0.00
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-122.30
-147.00
16.80%
Operating Profit Margin (Excl OI)
-1,143.60%
-2,090.80%
94.72%
USD in Million.
Direction Arrows
Net Sales

YoY Growth in year ended Dec 2024 is 47.92% vs 69.57% in Dec 2023

Direction Arrows
Consolidated Net Profit

YoY Growth in year ended Dec 2024 is 16.80% vs -25.75% in Dec 2023

stock-summaryCompany CV
About Prothena Corp. Plc stock-summary
stock-summary
Prothena Corp. Plc
Pharmaceuticals & Biotechnology
Prothena Corporation Public Limited Company is a global biotechnology company. The Company is focused on the discovery, development and commercialization of immunotherapies for the treatment of diseases that involve protein misfolding or cell adhesion. The Company's clinical pipeline of antibody-based product candidates targets a range of indications, including Amyloid Light-chain (AL) amyloidosis (NEOD001), Parkinson's disease and other related synucleinopathies (PRX002), and inflammatory diseases, including psoriasis and psoriatic arthritis (PRX003) and ATTR amyloidosis (PRX004). The Company has generated monoclonal antibodies that selectively bind to amyloidogenic (diseased) forms of the Transthyretin (TTR)-mediated amyloidosis (ATTR) protein. The Company's pipeline also includes late discovery-stage programs for which the Company is testing the efficacy of antibodies in preclinical models of diseases related to amyloid or cell adhesion.
Company Coordinates stock-summary
Company Details
Dublin 1, 25-28 North Wall Quay , DUBLIN None : A96 T927
stock-summary
Tel: 353 1 2362500
stock-summary
Registrar Details