Lyra Therapeutics, Inc.

  • Market Cap: Micro Cap
  • Industry: Pharmaceuticals & Biotechnology
  • ISIN: US55234L1052
USD
4.50
0.49 (12.22%)
  • Price Points
  • Score
  • Mojo Parameters
  • Total Return
  • News and Corporate Actions
  • Key factors
  • Shareholding
  • Financials
  • CompanyCV
stock-summaryPrice Point
High/Low

1Day

52 Week

Valuation
Technical
Day's Volume

CASH

46.69 k

Shareholding (Mar 2025)

FII

3.34%

Held by 25 FIIs

DII

78.62%

Held by 11 DIIs

Promoter

7.59%

How big is Lyra Therapeutics, Inc.?

22-Jun-2025

As of Jun 18, Lyra Therapeutics, Inc. has a market capitalization of 13.62 million, with net sales of 1.19 million and a net profit of -79.53 million over the last four quarters. The company reported shareholder's funds of 11.59 million and total assets of 66.35 million as of Dec 24.

Market Cap: As of Jun 18, Lyra Therapeutics, Inc. has a market capitalization of 13.62 million, categorizing it as a Micro Cap company.<BR><BR>Recent Quarterly Performance: For the latest four quarters, Lyra Therapeutics, Inc. reported net sales of 1.19 million and a net profit of -79.53 million.<BR><BR>Balance Sheet Snapshot: As of Dec 24, the company reported shareholder's funds of 11.59 million and total assets of 66.35 million.

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What does Lyra Therapeutics, Inc. do?

22-Jun-2025

Lyra Therapeutics, Inc. is a clinical-stage company developing localized drug delivery solutions for ENT diseases. As of March 2025, it has a market cap of $13.62 million, with net sales of $0 and a net loss of $9 million.

Overview: <BR>Lyra Therapeutics, Inc. is a clinical-stage therapeutics company focused on developing and commercializing novel integrated drug and delivery solutions for the localized treatment of ear, nose, and throat (ENT) diseases, operating within the Pharmaceuticals & Biotechnology industry and categorized as a micro-cap company.<BR><BR>Financial Snapshot: <BR>Most recent Net Sales: 0 Million (Quarterly Results - Mar 2025) <BR>Most recent Net Profit: -9 Million (Quarterly Results - Mar 2025) <BR>Market-cap: USD 13.62 Million (Micro Cap)<BR><BR>Key Metrics: <BR>P/E: NA (Loss Making) <BR>Industry P/E: NA <BR>Dividend Yield: 0.00% <BR>Debt Equity: -7.10 <BR>Return on Equity: -1,111.31% <BR>Price to Book: 3.52<BR><BR>Contact Details: <BR>Address: 480 Arsenal St, WATERTOWN MA: 02472-2891 <BR>Tel: 1 617 3734600 <BR>Fax: 1 302 6555049 <BR>Website: https://lyratherapeutics.com/

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Should I buy, sell or hold Lyra Therapeutics, Inc.?

22-Jun-2025

Who are in the management team of Lyra Therapeutics, Inc.?

22-Jun-2025

As of March 2022, the management team of Lyra Therapeutics, Inc. includes Dr. Maria Palasis as President, CEO, and Director, and Dr. Nancy Snyderman as a member of the Board of Directors.

As of March 2022, the management team of Lyra Therapeutics, Inc. includes Dr. Maria Palasis, who serves as the President, Chief Executive Officer, and Director. Additionally, Dr. Nancy Snyderman is a member of the Board of Directors.

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Is Lyra Therapeutics, Inc. overvalued or undervalued?

20-Sep-2025

As of August 12, 2025, Lyra Therapeutics, Inc. is considered overvalued with a valuation grade of "does not qualify" due to its high Price to Book Value of 8.31, negative earnings ratios, and a significantly low Return on Equity of -1111.31%, alongside poor stock performance compared to the S&P 500.

As of 12 August 2025, the valuation grade for Lyra Therapeutics, Inc. changed from risky to does not qualify, indicating a significant deterioration in its financial standing. The company is overvalued given its high Price to Book Value of 8.31 and negative EV to EBIT and EV to EBITDA ratios of -0.10, suggesting that it is not generating positive earnings or cash flow. Additionally, the Return on Equity (ROE) is alarmingly low at -1111.31%, further underscoring the company's struggles.<BR><BR>In comparison to its peers, Lyra Therapeutics, Inc. shows stark contrasts; for instance, 2seventy Bio, Inc. has a P/E ratio of 76.93, while Scilex Holding Co. and Generation Bio Co. also reflect negative valuations. The company's stock performance has been dismal, with a year-to-date return of -38.47% compared to the S&P 500's gain of 12.22%, and a staggering -98.94% return over the past five years against the S&P 500's 96.61%. This further reinforces the conclusion that Lyra Therapeutics is currently overvalued.

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Is Lyra Therapeutics, Inc. technically bullish or bearish?

20-Sep-2025

As of August 20, 2025, Lyra Therapeutics, Inc. shows a mildly bearish trend due to a bearish daily moving average and monthly Bollinger Band, despite a mildly bullish weekly MACD, with a year-to-date return of -38.47% compared to the S&P 500's 12.22%.

As of 20 August 2025, the technical trend for Lyra Therapeutics, Inc. has changed from mildly bullish to mildly bearish. The current stance is mildly bearish, driven by a bearish daily moving average and a bearish monthly Bollinger Band. The weekly MACD remains mildly bullish, but the overall indicators suggest weakness, particularly with the KST and OBV showing mixed signals. The stock has underperformed significantly against the S&P 500 across multiple periods, with a year-to-date return of -38.47% compared to the S&P 500's 12.22%.

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Unrated Stock - No Analysis Available
stock-summaryMojo Parameters
Mojo Parameters
Stock DNA
stock-summary
Industry

Pharmaceuticals & Biotechnology

stock-summary
Market cap

USD 11 Million (Micro Cap)

stock-summary
P/E

NA (Loss Making)

stock-summary
Industry P/E

NA

stock-summary
Dividend Yield

0.00%

stock-summary
Debt Equity

-15.56

stock-summary
Return on Equity

-2,041.12%

stock-summary
Price to Book

6.69

Revenue and Profits:
Net Sales:
0 Million
(Quarterly Results - Jun 2025)
Net Profit:
-7 Million
stock-summaryTotal Returns
Total Returns (Price + Dividend) stock-summary
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
-37.33%
0%
-37.33%
6 Months
-83.68%
0%
-83.68%
1 Year
-57.18%
0%
-57.18%
2 Years
-97.51%
0%
-97.51%
3 Years
28.57%
0%
28.57%
4 Years
-98.16%
0%
-98.16%
5 Years
-99.3%
0%
-99.3%

Lyra Therapeutics, Inc. for the last several years.

Risk Adjusted Returns v/s stock-summary
stock-summaryNews & Corporate Actions
News
Announcements stock-summary
Icon
No announcement available
Corporate Actions stock-summary
Icon
No corporate action available
stock-summaryKey Factors
Quality key factors stock-summary
Factor
Value
Sales Growth (5y)
15.34%
EBIT Growth (5y)
-2.81%
EBIT to Interest (avg)
-50.16
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-7.10
Sales to Capital Employed (avg)
0.06
Tax Ratio
0.04%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
81.44%
ROCE (avg)
0
ROE (avg)
0
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
8.31
EV to EBIT
-0.10
EV to EBITDA
-0.10
EV to Capital Employed
-0.20
EV to Sales
3.96
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
Negative Capital Employed
ROE (Latest)
-1111.31%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Bearish
Mildly Bullish
RSI
No Signal
No Signal
Bollinger Bands
Bearish
Bearish
Moving Averages
Bearish (Daily)
KST
Bearish
Bearish
Dow Theory
Mildly Bearish
Mildly Bearish
OBV
Mildly Bearish
Mildly Bearish
stock-summary Technical Indicator Scale: Bearish, Mildly Bearish, Sideways, Mildly Bullish, Bullish  Turned 
stock-summaryShareholding
Shareholding Snapshot : Mar 2025stock-summary
Shareholding Compare (%holding) stock-summary
Majority shareholders

Domestic Funds

Domestic Funds

Held in 13 Schemes (10.44%)

Foreign Institutions

Held by 25 Foreign Institutions (3.34%)

Strategic Entities with highest holding

Highest Public shareholder

stock-summaryFinancial
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        "prefix": "Consolidated Net Profit ",
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          "field": "Interest",
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        {
          "field": "Consolidate Net Profit",
          "val1": "-7.40",
          "val2": "-8.50",
          "chgp": "12.94%",
          "chgp_class": "positive"
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          "field": "Operating Profit Margin (Excl OI)",
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          "val2": "-43,475.40%",
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Quarterly Results Snapshot (Consolidated) - Jun'25 - QoQstock-summary
Jun'25
Mar'25
Change(%)
Net Sales
0.20
0.20
Operating Profit (PBDIT) excl Other Income
-8.20
-7.80
-5.13%
Interest
0.00
0.00
Exceptional Items
-0.40
-0.90
55.56%
Consolidate Net Profit
-7.40
-8.50
12.94%
Operating Profit Margin (Excl OI)
-46,054.60%
-43,475.40%
-257.92%
USD in Million.
Net Sales

QoQ Growth in quarter ended Jun 2025 is 0.00% vs 0.00% in Mar 2025

Direction Arrows
Consolidated Net Profit

QoQ Growth in quarter ended Jun 2025 is 12.94% vs 22.73% in Mar 2025

Annual Results Snapshot (Consolidated) - Dec'24stock-summary
Dec'24
Dec'23
Change(%)
Net Sales
1.50
1.60
-6.25%
Operating Profit (PBDIT) excl Other Income
-60.30
-65.30
7.66%
Interest
0.00
0.00
Exceptional Items
-35.60
-1.60
-2,125.00%
Consolidate Net Profit
-93.40
-62.70
-48.96%
Operating Profit Margin (Excl OI)
-39,591.30%
-42,059.10%
246.78%
USD in Million.
Direction Arrows
Net Sales

YoY Growth in year ended Dec 2024 is -6.25% vs 14.29% in Dec 2023

Direction Arrows
Consolidated Net Profit

YoY Growth in year ended Dec 2024 is -48.96% vs -13.38% in Dec 2023

stock-summaryCompany CV
About Lyra Therapeutics, Inc. stock-summary
stock-summary
Lyra Therapeutics, Inc.
Pharmaceuticals & Biotechnology
Lyra Therapeutics, Inc. is a clinical-stage therapeutics company focused on the development and commercialization of novel integrated drug and delivery solutions for the localized treatment of patients with ear, nose and throat (ENT) diseases. The Company’s product candidates, LYR-210 and LYR-220, are bioresorbable polymeric matrices designed to be administered in a non-invasive, in-office procedure and intended to deliver up to six months of continuous drug therapy to the sinonasal passages for the treatment of chronic rhinosinusitis (CRS). LYR-210 is an anti-inflammatory implantable drug matrix based on its XTreo platform that is designed to locally elute mometasone furoate (MF) to the inflamed mucosal tissue for up to six months in surgically-naive CRS patients who fail medical management. It has developed LYR-220 for use in CRS patients who continue to require treatment to manage CRS symptoms despite having had sinus surgery.
Company Coordinates stock-summary
Company Details
480 Arsenal St , WATERTOWN MA : 02472-2891
Registrar Details