Axsome Therapeutics, Inc.

  • Market Cap: Small Cap
  • Industry: Pharmaceuticals & Biotechnology
  • ISIN: US05464T1043
USD
161.78
4.94 (3.15%)
  • Price Points
  • Score
  • Mojo Parameters
  • Total Return
  • News and Corporate Actions
  • Key factors
  • Shareholding
  • Financials
  • CompanyCV
stock-summaryPrice Point
High/Low

1Day

52 Week

Valuation
Technical
Day's Volume

CASH

434.89 k

Shareholding (Dec 2025)

FII

12.13%

Held by 152 FIIs

DII

54.17%

Held by 38 DIIs

Promoter

1.19%

How big is Axsome Therapeutics, Inc.?

22-Jun-2025

As of Jun 18, Axsome Therapeutics, Inc. has a market capitalization of $5.00 billion, with net sales of $432.16 million and a net profit of -$278.26 million over the last four quarters. The company reported shareholder's funds of $57.02 million and total assets of $568.50 million as of Dec 24.

Market Cap: As of Jun 18, Axsome Therapeutics, Inc. has a market capitalization of 5,002.41 million, categorizing it as a Small Cap company.<BR><BR>Recent Quarterly Performance: For the latest four quarters, Axsome Therapeutics, Inc. reported net sales of 432.16 million and a net profit of -278.26 million.<BR><BR>Balance Sheet Snapshot: As of Dec 24, the company reported shareholder's funds of 57.02 million and total assets of 568.50 million.

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What does Axsome Therapeutics, Inc. do?

22-Jun-2025

Axsome Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing therapies for central nervous system disorders. As of March 2025, it reported net sales of $121 million and a net loss of $59 million, with a market cap of approximately $5 billion.

Overview: <BR>Axsome Therapeutics, Inc. is a clinical-stage biopharmaceutical company engaged in developing therapies for the management of central nervous system (CNS) disorders, including pain, and operates in the Pharmaceuticals & Biotechnology industry within the small-cap market.<BR><BR>Financial Snapshot: <BR>Most recent Net Sales: 121 Million (Quarterly Results - Mar 2025) <BR>Most recent Net Profit: -59 Million (Quarterly Results - Mar 2025) <BR>Market-cap: USD 5,002.41 Million (Small Cap)<BR><BR>Key Metrics: <BR>P/E: NA (Loss Making) <BR>Industry P/E: NA <BR>Dividend Yield: 0.00% <BR>Debt Equity: -2.13 <BR>Return on Equity: -464.66% <BR>Price to Book: 94.02<BR><BR>Contact Details: <BR>Address: 22 CORTLANDT STREET, 16TH FLOOR, NEW YORK NY: 10007 <BR>Tel: 1 212 3323241 <BR>Fax: 1 212 3200245 <BR>Website: http://axsome.com/

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Should I buy, sell or hold Axsome Therapeutics, Inc.?

22-Jun-2025

Who are in the management team of Axsome Therapeutics, Inc.?

22-Jun-2025

As of March 2022, the management team of Axsome Therapeutics, Inc. includes Dr. Herriot Tabuteau as Chairman, President, and CEO, with Dr. Roger Jeffs as Lead Independent Director, and Dr. Mark Coleman and Mr. Mark Saad as Independent Directors.

As of March 2022, the management team of Axsome Therapeutics, Inc. includes Dr. Herriot Tabuteau, who serves as the Chairman of the Board, President, Chief Executive Officer, and is also the Founder. Additionally, Dr. Roger Jeffs holds the position of Lead Independent Director, while Dr. Mark Coleman and Mr. Mark Saad serve as Independent Directors.

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Is Axsome Therapeutics, Inc. overvalued or undervalued?

20-Sep-2025

As of August 9, 2022, Axsome Therapeutics is considered a risky investment due to its high price-to-book value of 103.56 and negative earnings metrics, despite a strong year-to-date return of 40.21%.

As of 9 August 2022, the valuation grade for Axsome Therapeutics, Inc. moved from does not qualify to risky, indicating increased caution regarding its investment potential. The company appears overvalued, particularly given its high price-to-book value of 103.56 and negative earnings metrics, such as an EV to EBITDA ratio of -23.34 and an ROE of -464.66%. In comparison, BioMarin Pharmaceutical, Inc. has a fair valuation with a P/E of 15.17, while BridgeBio Pharma, Inc. is also classified as risky with a P/E of -14.12.<BR><BR>Despite a strong year-to-date return of 40.21% compared to the S&P 500's 12.22%, the overall financial metrics suggest that Axsome Therapeutics is not a sound investment at its current valuation levels.

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Is Axsome Therapeutics, Inc. technically bullish or bearish?

20-Sep-2025

As of August 18, 2025, Axsome Therapeutics shows a bullish trend supported by strong technical indicators, outperforming the S&P 500 with a 29.59% annual return compared to 17.14%.

As of 18 August 2025, the technical trend has changed from mildly bullish to bullish. The current stance is bullish with strong indicators supporting this view. The MACD is bullish on both the weekly and monthly time frames, and the moving averages are bullish on the daily. Bollinger Bands show a bullish signal on the weekly and a mildly bullish signal on the monthly. The KST is bullish for both weekly and monthly periods. However, Dow Theory indicates a mildly bearish stance on the weekly while being mildly bullish on the monthly, and the OBV shows a mildly bearish signal on the weekly but mildly bullish on the monthly.<BR><BR>In terms of performance, Axsome Therapeutics has outperformed the S&P 500 over the year with a return of 29.59% compared to the S&P 500's 17.14%, and significantly over the YTD with a return of 40.21% against the S&P 500's 12.22%.

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iScoreScore
Click here to find our call on this stock
Strong Sell
Sell
Hold
Buy
Strong Buy

Dashboard

1

With a growth in Net Sales of 14.62%, the company declared Very Positive results in Sep 25

  • OPERATING CASH FLOW(Y) Highest at USD -100.95 MM
  • NET SALES(Q) Highest at USD 170.99 MM
  • RAW MATERIAL COST(Y) Fallen by -1.84% (YoY)
2

Risky -

3

Reducing Promoter Confidence

4

Market Beating performance in long term as well as near term

stock-summaryMojo Parameters

Mojo Parameters

Stock DNA

stock-summary
Industry

Pharmaceuticals & Biotechnology

stock-summary
Market cap

USD 8,094 Million (Small Cap)

stock-summary
P/E

NA (Loss Making)

stock-summary
Industry P/E

NA

stock-summary
Dividend Yield

0.00%

stock-summary
Debt Equity

-1.82

stock-summary
Return on Equity

-273.39%

stock-summary
Price to Book

109.78

Revenue and Profits:
Net Sales:
196 Million
(Quarterly Results - Dec 2025)
Net Profit:
-29 Million
stock-summaryTotal Returns
Total Returns (Price + Dividend) stock-summary
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
5.3%
0%
5.3%
6 Months
36.21%
0%
36.21%
1 Year
25.25%
0%
25.25%
2 Years
100.57%
0%
100.57%
3 Years
161.1%
0%
161.1%
4 Years
349.64%
0%
349.64%
5 Years
176.83%
0%
176.83%

Axsome Therapeutics, Inc. for the last several years.

Risk Adjusted Returns v/s stock-summary
stock-summaryNews & Corporate Actions

News

Icon
No Recent News for the Company

Announcements stock-summary

Icon
No announcement available

Corporate Actions stock-summary

Icon
No corporate action available
stock-summaryKey Factors

Quality key factors stock-summary

Factor
Value
Sales Growth (5y)
254.80%
EBIT Growth (5y)
-150.60%
EBIT to Interest (avg)
-26.97
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-2.20
Sales to Capital Employed (avg)
1.20
Tax Ratio
0.03%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
86.64%
ROCE (avg)
0
ROE (avg)
0

Valuation key factors

Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
109.78
EV to EBIT
-40.85
EV to EBITDA
-42.77
EV to Capital Employed
-131.19
EV to Sales
14.18
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
Negative Capital Employed
ROE (Latest)
-273.39%

Technicals key factors

Indicator
Weekly
Monthly
MACD
Mildly Bearish
Bullish
RSI
No Signal
No Signal
Bollinger Bands
Mildly Bearish
Mildly Bullish
Moving Averages
Mildly Bullish (Daily)
KST
Mildly Bearish
Bullish
Dow Theory
Mildly Bearish
Mildly Bearish
OBV
Mildly Bullish
No Trend
stock-summary Technical Indicator Scale: Bearish, Mildly Bearish, Sideways, Mildly Bullish, Bullish  Turned 
stock-summaryShareholding
Shareholding Snapshot : Dec 2025stock-summary
Shareholding Compare (%holding) stock-summary
Majority shareholders

Domestic Funds

Domestic Funds

Held in 83 Schemes (32.52%)

Foreign Institutions

Held by 152 Foreign Institutions (12.13%)

Strategic Entities with highest holding

Highest Public shareholder

stock-summaryFinancial
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          "field": "Consolidate Net Profit",
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          "val2": "-47.20",
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          "field": "Operating Profit Margin (Excl OI)",
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          "chgp": "71.89%",
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Quarterly Results Snapshot (Consolidated) - Dec'25 - QoQstock-summary

Dec'25
Sep'25
Change(%)
Net Sales
196.00
171.00
14.62%
Operating Profit (PBDIT) excl Other Income
-33.80
-30.50
-10.82%
Interest
3.20
3.40
-5.88%
Exceptional Items
9.10
-13.20
168.94%
Consolidate Net Profit
-28.60
-47.20
39.41%
Operating Profit Margin (Excl OI)
-183.80%
-192.50%
0.87%
USD in Million.
Direction Arrows
Net Sales

QoQ Growth in quarter ended Dec 2025 is 14.62% vs 14.00% in Sep 2025

Direction Arrows
Consolidated Net Profit

QoQ Growth in quarter ended Dec 2025 is 39.41% vs 1.67% in Sep 2025

Annual Results Snapshot (Consolidated) - Dec'25stock-summary

Dec'25
Dec'24
Change(%)
Net Sales
638.50
385.70
65.54%
Operating Profit (PBDIT) excl Other Income
-160.20
-244.50
34.48%
Interest
15.90
21.60
-26.39%
Exceptional Items
-7.90
-28.10
71.89%
Consolidate Net Profit
-183.20
-287.20
36.21%
Operating Profit Margin (Excl OI)
-265.10%
-654.50%
38.94%
USD in Million.
Direction Arrows
Net Sales

YoY Growth in year ended Dec 2025 is 65.54% vs 42.54% in Dec 2024

Direction Arrows
Consolidated Net Profit

YoY Growth in year ended Dec 2025 is 36.21% vs -20.07% in Dec 2024

stock-summaryCompany CV
About Axsome Therapeutics, Inc. stock-summary
stock-summary
Axsome Therapeutics, Inc.
Pharmaceuticals & Biotechnology
Axsome Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is engaged in developing therapies for the management of central nervous system (CNS) disorders, including pain. It operates in the business of developing novel therapies for the management of CNS disorders segment. Its product candidate, AXS-02 (disodium zoledronate tetrahydrate), is an oral, targeted, non opioid therapeutic for chronic pain. It is developing AXS 02 for the treatment of pain in over three conditions, such as complex regional pain syndrome (CRPS); knee osteoarthritis (OA) associated with bone marrow lesions (BMLs), and chronic low back pain (CLBP), associated with type I, or mixed type I and type II Modic changes (MCs). Its product candidate, AXS 05, is a fixed dose combination of dextromethorphan (DM) and bupropion. It is developing AXS 05 for the treatment of over two conditions, such as treatment resistant depression (TRD), and agitation in patients with Alzheimer's disease (AD).
Company Coordinates stock-summary
Company Details
22 CORTLANDT STREET, 16TH FLOOR , NEW YORK NY : 10007
stock-summary
Tel: 1 212 3323241
stock-summary
Registrar Details