Spruce Biosciences, Inc.

  • Market Cap: Micro Cap
  • Industry: Pharmaceuticals & Biotechnology
  • ISIN: US85209E1091
USD
90.44
1.24 (1.39%)
  • Price Points
  • Score
  • Mojo Parameters
  • Total Return
  • News and Corporate Actions
  • Key factors
  • Shareholding
  • Financials
  • CompanyCV
stock-summaryPrice Point
High/Low

1Day

52 Week

Valuation
Technical
Day's Volume

CASH

47.71 k

Shareholding (Mar 2025)

FII

27.48%

Held by 14 FIIs

DII

26.29%

Held by 7 DIIs

Promoter

43.14%

How big is Spruce Biosciences, Inc.?

22-Jun-2025

As of Jun 18, Spruce Biosciences, Inc. has a market capitalization of 3.07 million, with net sales of 2.91 million and a net profit of -55.45 million over the last four quarters. The company reported shareholder's funds of 28.82 million and total assets of 45.21 million as of Dec 24.

Market Cap: As of Jun 18, Spruce Biosciences, Inc. has a market capitalization of 3.07 million, categorizing it as a Micro Cap company.<BR><BR>Recent Quarterly Performance: For the latest four quarters, Spruce Biosciences reported net sales of 2.91 million and a net profit of -55.45 million.<BR><BR>Balance Sheet Snapshot: As of Dec 24, the company reported shareholder's funds of 28.82 million and total assets of 45.21 million.

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What does Spruce Biosciences, Inc. do?

22-Jun-2025

Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing therapies for endocrine disorders, particularly congenital adrenal hyperplasia (CAH). It has a market cap of $3.07 million and reported a net profit loss of $14 million as of March 2025.

Overview: <BR>Spruce Biosciences, Inc. is a biopharmaceutical company focused on developing and commercializing therapies for endocrine disorders, specifically targeting congenital adrenal hyperplasia (CAH). It operates within the Pharmaceuticals & Biotechnology industry and is categorized as a micro-cap company.<BR><BR>Financial Snapshot: <BR>Most recent Net Profit: -14 Million (Quarterly Results - Mar 2025) <BR>Market cap: USD 3.07 Million (Micro Cap)<BR><BR>Key Metrics: <BR>P/E: NA (Loss Making) <BR>Industry P/E: NA <BR>Dividend Yield: 0.00% <BR>Debt Equity: -1.56 <BR>Return on Equity: -361.86% <BR>Price to Book: 0.20<BR><BR>Contact Details: <BR>Address: 2001 Junipero Serra Blvd., Suite 640, DALY CITY CA: 94104-5401 <BR>Tel: 1 302 6365400 <BR>Fax: 1 302 6365454 <BR>Website: http://www.sprucebiosciences.com/

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Should I buy, sell or hold Spruce Biosciences, Inc.?

22-Jun-2025

Who are in the management team of Spruce Biosciences, Inc.?

22-Jun-2025

As of March 2022, the management team of Spruce Biosciences, Inc. includes Mr. Michael Grey (Chairman of the Board), Mr. Richard King (CEO and Director), and Dr. Niall O'Donnell (Director).

As of March 2022, the management team of Spruce Biosciences, Inc. includes Mr. Michael Grey, who serves as the Chairman of the Board, and Mr. Richard King, who is the Chief Executive Officer and a Director. Additionally, Dr. Niall O'donnell is also a Director on the board.

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Is Spruce Biosciences, Inc. overvalued or undervalued?

20-Sep-2025

As of May 15, 2023, Spruce Biosciences, Inc. is considered risky and overvalued due to its low Price to Book Value of 0.18, an EV to EBITDA ratio of 0.37, and significant underperformance with a stock return of -73.54% over the past year, despite a high ROCE of 670.25% and a concerning negative ROE of -361.86%.

As of 15 May 2023, the valuation grade for Spruce Biosciences, Inc. has moved from does not qualify to risky, indicating increased uncertainty regarding its valuation. The company appears to be overvalued, particularly given its low Price to Book Value of 0.18 and an EV to EBITDA ratio of 0.37, which suggests that investors are paying a premium relative to its earnings potential. Additionally, the ROCE stands at an impressive 670.25%, yet the negative ROE of -361.86% raises concerns about profitability and financial health.<BR><BR>In comparison to its peers, Spruce Biosciences has a P/E ratio that is not applicable due to its loss-making status, while CARA Therapeutics, Inc. has a P/E of -9.4978 and NGM Biopharmaceuticals, Inc. shows a P/E of -0.9351, highlighting the challenging environment for these companies. Over the past year, Spruce Biosciences has significantly underperformed, with a stock return of -73.54% compared to a 17.14% return for the S&P 500, reinforcing the notion that the stock may be overvalued in the current market context.

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Is Spruce Biosciences, Inc. technically bullish or bearish?

20-Sep-2025

As of September 5, 2025, Spruce Biosciences, Inc. shows a bullish trend despite short-term bearish signals, with year-to-date and one-year returns significantly underperforming the S&P 500.

As of 5 September 2025, the technical trend for Spruce Biosciences, Inc. has changed from mildly bullish to bullish. The current stance is bullish, with key indicators supporting this view including a bullish monthly RSI and a bullish weekly KST. However, the daily moving averages indicate a mildly bearish trend, which suggests some short-term weakness. <BR><BR>In terms of multi-period returns, the stock has significantly underperformed compared to the S&P 500, with a year-to-date return of -71.8% versus the S&P's 12.22%, and a one-year return of -73.54% compared to the S&P's 17.14%.

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Unrated Stock - No Analysis Available
stock-summaryMojo Parameters
Mojo Parameters
Stock DNA
stock-summary
Industry

Pharmaceuticals & Biotechnology

stock-summary
Market cap

USD 5 Million (Micro Cap)

stock-summary
P/E

NA (Loss Making)

stock-summary
Industry P/E

NA

stock-summary
Dividend Yield

0.00%

stock-summary
Debt Equity

-1.15

stock-summary
Return on Equity

-370.25%

stock-summary
Price to Book

0.38

Revenue and Profits:
Net Sales:
(Quarterly Results - Jun 2025)
Net Profit:
-2 Million
stock-summaryTotal Returns
Total Returns (Price + Dividend) stock-summary
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
1009.69%
0%
1009.69%
6 Months
1755.18%
0%
1755.18%
1 Year
124.14%
0%
124.14%
2 Years
-19.07%
0%
-19.07%
3 Years
7764.35%
0%
7764.35%
4 Years
-48.25%
0%
-48.25%
5 Years
-96.0%
0%
-96.0%

Spruce Biosciences, Inc. for the last several years.

Risk Adjusted Returns v/s stock-summary
stock-summaryNews & Corporate Actions
News
Announcements stock-summary
Icon
No announcement available
Corporate Actions stock-summary
Icon
No corporate action available
stock-summaryKey Factors
Quality key factors stock-summary
Factor
Value
Sales Growth (5y)
23.15%
EBIT Growth (5y)
-8.06%
EBIT to Interest (avg)
-47.00
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-1.56
Sales to Capital Employed (avg)
0.11
Tax Ratio
0
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
94.21%
ROCE (avg)
0
ROE (avg)
0
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
0.18
EV to EBIT
0.37
EV to EBITDA
0.37
EV to Capital Employed
2.46
EV to Sales
-7.32
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
670.25%
ROE (Latest)
-361.86%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Bullish
Mildly Bullish
RSI
Bearish
Bearish
Bollinger Bands
Mildly Bullish
Mildly Bullish
Moving Averages
Bullish (Daily)
KST
Bullish
Mildly Bearish
Dow Theory
No Trend
No Trend
OBV
Mildly Bullish
No Trend
stock-summary Technical Indicator Scale: Bearish, Mildly Bearish, Sideways, Mildly Bullish, Bullish  Turned 
stock-summaryShareholding
Shareholding Snapshot : Mar 2025stock-summary
Shareholding Compare (%holding) stock-summary
Majority shareholders

Strategic Entities

Domestic Funds

Held in 6 Schemes (3.08%)

Foreign Institutions

Held by 14 Foreign Institutions (27.48%)

Strategic Entities with highest holding

Highest Public shareholder

stock-summaryFinancial
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          "field": "Consolidate Net Profit",
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          "field": "Operating Profit Margin (Excl OI)",
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Quarterly Results Snapshot (Consolidated) - Jun'25 - QoQstock-summary
Jun'25
Mar'25
Change(%)
Net Sales
0.00
0.00
Operating Profit (PBDIT) excl Other Income
-2.70
-14.50
81.38%
Interest
0.00
0.00
Exceptional Items
0.50
0.00
Consolidate Net Profit
-2.10
-14.00
85.00%
Operating Profit Margin (Excl OI)
0.00%
0.00%
NA
USD in Million.
Direction Arrows
Net Sales

QoQ Growth in quarter ended Jun 2025 is 0.00% vs -100.00% in Mar 2025

Direction Arrows
Consolidated Net Profit

QoQ Growth in quarter ended Jun 2025 is 85.00% vs 40.68% in Mar 2025

Annual Results Snapshot (Consolidated) - Dec'24stock-summary
Dec'24
Dec'23
Change(%)
Net Sales
4.90
10.10
-51.49%
Operating Profit (PBDIT) excl Other Income
-56.10
-51.90
-8.09%
Interest
0.30
0.50
-40.00%
Exceptional Items
0.00
0.00
Consolidate Net Profit
-53.00
-47.90
-10.65%
Operating Profit Margin (Excl OI)
-11,433.70%
-5,153.40%
-628.03%
USD in Million.
Direction Arrows
Net Sales

YoY Growth in year ended Dec 2024 is -51.49% vs 0.00% in Dec 2023

Direction Arrows
Consolidated Net Profit

YoY Growth in year ended Dec 2024 is -10.65% vs -3.68% in Dec 2023

stock-summaryCompany CV
About Spruce Biosciences, Inc. stock-summary
stock-summary
Spruce Biosciences, Inc.
Pharmaceuticals & Biotechnology
Spruce Biosciences, Inc. is a biopharmaceutical company. The Company is focused on developing and commercializing therapies for endocrine disorders. The Company's development product candidate, tildacerfont, is a non-steroidal therapy that offers disease control for patients suffering from congenital adrenal hyperplasia (CAH). Tildacerfont is a non-steroidal, oral antagonist of the corticotropin-releasing hormone receptor 1 (CRF1) receptor, which is the receptor for corticotropin-releasing factor (CRF). By blocking the CRF1 receptor, tildacerfont enables to address the uncontrolled cortisol feedback regulatory pathway in CAH and reduce the production of adrenocorticotropic hormone (ACTH) in the pituitary, limiting the amount of androgen produced downstream from the adrenal gland. Tildacerfont also enables treating physicians to lower the supraphysiologic glucocorticoid doses given to CAH patients to near physiologic levels.
Company Coordinates stock-summary
Company Details
2001 Junipero Serra Blvd., Suite 640 , DALY CITY CA : 94104-5401
Registrar Details