Syndax Pharmaceuticals, Inc.

  • Market Cap: Small Cap
  • Industry: Pharmaceuticals & Biotechnology
  • ISIN: US87164F1057
USD
19.74
0.95 (5.06%)
  • Price Points
  • Score
  • Mojo Parameters
  • Total Return
  • News and Corporate Actions
  • Key factors
  • Shareholding
  • Financials
  • CompanyCV
stock-summaryPrice Point
High/Low

1Day

52 Week

Valuation
Technical
Day's Volume

CASH

1.49 M

Shareholding (Mar 2025)

FII

16.09%

Held by 109 FIIs

DII

45.84%

Held by 44 DIIs

Promoter

6.60%

How big is Syndax Pharmaceuticals, Inc.?

22-Jun-2025

As of Jun 18, Syndax Pharmaceuticals, Inc. has a market capitalization of 829.50 million, with net sales of 43.72 million and a net loss of 331.21 million over the latest four quarters. Shareholder's funds are reported at 288.12 million, and total assets amount to 724.82 million.

As of Jun 18, Syndax Pharmaceuticals, Inc. has a market capitalization of 829.50 million, categorizing it as a Small Cap company.<BR><BR>As of Jun 18, the company reported net sales of 43.72 million for the latest four quarters, while the net profit for the same period was a loss of 331.21 million.<BR><BR>As of Dec 24, the reporting period shows shareholder's funds at 288.12 million and total assets amounting to 724.82 million.

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What does Syndax Pharmaceuticals, Inc. do?

22-Jun-2025

Syndax Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company focused on developing combination therapies for cancer. As of March 2025, it reported net sales of $20 million and a net loss of $85 million, with a market cap of $829.50 million.

Overview:<BR>Syndax Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company focused on developing combination therapies for multiple cancer indications within the Pharmaceuticals & Biotechnology industry.<BR><BR>Financial Snapshot:<BR>Most recent Net Sales: 20 Million (Quarterly Results - Mar 2025) <BR>Most recent Net Profit: -85 Million (Quarterly Results - Mar 2025) <BR>Market-cap: USD 829.50 Million (Small Cap) <BR><BR>Key Metrics:<BR>P/E: NA (Loss Making) <BR>Industry P/E: NA <BR>Dividend Yield: 0.00% <BR>Debt Equity: -0.78 <BR>Return on Equity: -154.01% <BR>Price to Book: 3.86 <BR><BR>Contact Details:<BR>Address: Building D, 35 Gatehouse Dr Fl 3, WALTHAM MA : 02451-1215 <BR>Tel: 1 781 4191400 <BR>Fax: 1 781 4191420 <BR>Website: http://www.syndax.com/

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Should I buy, sell or hold Syndax Pharmaceuticals, Inc.?

22-Jun-2025

Who are in the management team of Syndax Pharmaceuticals, Inc.?

22-Jun-2025

As of March 2022, the management team of Syndax Pharmaceuticals, Inc. includes CEO Dr. Briggs Morrison, President Michael Metzger, and several independent directors, including Mr. Dennis Podlesak as Chairman. They oversee the company's operations and strategic direction.

As of March 2022, the management team of Syndax Pharmaceuticals, Inc. includes the following individuals:<BR><BR>- Mr. Dennis Podlesak, Independent Chairman of the Board<BR>- Mr. Michael Metzger, President, Chief Operating Officer, Director<BR>- Dr. Briggs Morrison, Chief Executive Officer, Director<BR>- Dr. Fabrice Egros, Independent Director<BR>- Ms. Jennifer Jarrett, Independent Director<BR>- Mr. Keith Katkin, Independent Director<BR>- Mr. Pierre Legault, Independent Director<BR>- Mr. William Meury, Independent Director<BR><BR>This team is responsible for overseeing the company's operations and strategic direction.

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Is Syndax Pharmaceuticals, Inc. overvalued or undervalued?

20-Sep-2025

As of August 1, 2024, Syndax Pharmaceuticals is considered risky and overvalued due to its high Price to Book Value of 4.58, negative EV to EBIT and EV to EBITDA ratios, and alarmingly low ROCE and ROE, while it has significantly underperformed the S&P 500 over the past year and three years.

As of 1 August 2024, the valuation grade for Syndax Pharmaceuticals, Inc. has moved from does not qualify to risky, indicating a shift towards a more cautious outlook. The company appears to be overvalued given its high Price to Book Value of 4.58 and negative EV to EBIT and EV to EBITDA ratios of -2.38, which suggest significant operational challenges. Additionally, the Return on Capital Employed (ROCE) and Return on Equity (ROE) are alarmingly low at -730.60% and -154.01%, respectively, further underscoring the company's financial difficulties.<BR><BR>In comparison to its peers, Syndax's P/E ratio is not applicable due to its loss-making status, while Protagonist Therapeutics, Inc. is considered very expensive with a P/E of 67.1750, and Aurinia Pharmaceuticals, Inc. is fairly valued with a P/E of 20.8727. The stock has underperformed against the S&P 500 across multiple periods, with a 1-year return of -14.17% compared to the S&P 500's 17.14%, and a 3-year return of -33.23% versus 70.41% for the index, reinforcing the notion that Syndax is currently overvalued.

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Is Syndax Pharmaceuticals, Inc. technically bullish or bearish?

20-Sep-2025

As of September 8, 2025, Syndax Pharmaceuticals, Inc. shows a mildly bearish trend due to mixed signals from various indicators, with underperformance against the S&P 500 over the past week and month.

As of 8 September 2025, the technical trend for Syndax Pharmaceuticals, Inc. has changed from mildly bullish to mildly bearish. The weekly MACD and KST are bullish, while the monthly MACD and KST are bearish, indicating mixed signals across different time frames. The daily moving averages are bullish, but the Bollinger Bands and Dow Theory suggest a bearish stance on the monthly level. The stock has underperformed against the S&P 500 over the past week and month, with returns of -5.62% and -2.65% compared to the S&P's gains of 1.05% and 2.33%, respectively. Overall, the current technical stance is mildly bearish, reflecting weakness in the longer-term indicators.

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iScoreScore
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Strong Sell
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Hold
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Strong Buy

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Dashboard
1

Poor Management Efficiency with a low ROE of 0.83%

  • The company has been able to generate a Return on Equity (avg) of 0.83% signifying low profitability per unit of shareholders funds
2

The company has declared Negative results for the last 11 consecutive quarters

3

Risky - Negative EBITDA

4

Rising Promoter Confidence

stock-summaryMojo Parameters
Mojo Parameters
Stock DNA
stock-summary
Industry

Pharmaceuticals & Biotechnology

stock-summary
Market cap

USD 1,407 Million (Small Cap)

stock-summary
P/E

NA (Loss Making)

stock-summary
Industry P/E

NA

stock-summary
Dividend Yield

0.00%

stock-summary
Debt Equity

-0.71

stock-summary
Return on Equity

-212.79%

stock-summary
Price to Book

8.94

Revenue and Profits:
Net Sales:
38 Million
(Quarterly Results - Jun 2025)
Net Profit:
-72 Million
stock-summaryTotal Returns
Total Returns (Price + Dividend) stock-summary
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
22.38%
0%
22.38%
6 Months
76.33%
0%
76.33%
1 Year
18.77%
0%
18.77%
2 Years
19.13%
0%
19.13%
3 Years
-21.26%
0%
-21.26%
4 Years
22.61%
0%
22.61%
5 Years
-18.23%
0%
-18.23%

Syndax Pharmaceuticals, Inc. for the last several years.

Risk Adjusted Returns v/s stock-summary
stock-summaryKey Factors
Quality key factors stock-summary
Factor
Value
Sales Growth (5y)
119.91%
EBIT Growth (5y)
-230.17%
EBIT to Interest (avg)
-75.64
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-0.78
Sales to Capital Employed (avg)
0.06
Tax Ratio
0
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
0
ROE (avg)
0.83%
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
4.58
EV to EBIT
-2.38
EV to EBITDA
-2.38
EV to Capital Employed
17.37
EV to Sales
18.69
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
-730.60%
ROE (Latest)
-154.01%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Bullish
Mildly Bullish
RSI
No Signal
No Signal
Bollinger Bands
Bullish
Bullish
Moving Averages
Bullish (Daily)
KST
Mildly Bearish
Bearish
Dow Theory
Mildly Bullish
Mildly Bullish
OBV
Mildly Bearish
No Trend
stock-summary Technical Indicator Scale: Bearish, Mildly Bearish, Sideways, Mildly Bullish, Bullish  Turned 
stock-summaryShareholding
Shareholding Snapshot : Mar 2025stock-summary
Shareholding Compare (%holding) stock-summary
Majority shareholders

Domestic Funds

Domestic Funds

Held in 63 Schemes (31.47%)

Foreign Institutions

Held by 109 Foreign Institutions (16.09%)

Strategic Entities with highest holding

Highest Public shareholder

stock-summaryFinancial
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  {
    "link": "quarterly",
    "btn_text": "All Quarterly Results",
    "header": "Quarterly Results Snapshot (Consolidated) - Jun'25 - YoY",
    "rhs": [
      {
        "prefix": "Net Sales ",
        "suffix": "YoY Growth in quarter ended Jun 2025 is 985.71% vs 0.00% in Jun 2024",
        "dir": 1
      },
      {
        "prefix": "Consolidated Net Profit ",
        "suffix": "YoY Growth in quarter ended Jun 2025 is -5.43% vs -52.69% in Jun 2024",
        "dir": 1
      }
    ],
    "table": {
      "header": [
        "Jun'25",
        "Jun'24",
        "Change(%)"
      ],
      "body": [
        {
          "field": "Net Sales",
          "val1": "38.00",
          "val2": "3.50",
          "chgp": "985.71%",
          "chgp_class": "positive"
        },
        {
          "field": "Operating Profit (PBDIT) excl Other Income",
          "val1": "-69.40",
          "val2": "-74.20",
          "chgp": "6.47%",
          "chgp_class": "positive"
        },
        {
          "field": "Interest",
          "val1": "7.90",
          "val2": "0.00",
          "chgp": "",
          "chgp_class": "neutral"
        },
        {
          "field": "Exceptional Items",
          "val1": "0.00",
          "val2": "0.00",
          "chgp": "",
          "chgp_class": "neutral"
        },
        {
          "field": "Consolidate Net Profit",
          "val1": "-71.80",
          "val2": "-68.10",
          "chgp": "-5.43%",
          "chgp_class": "negative"
        },
        {
          "field": "Operating Profit Margin (Excl OI)",
          "val1": "-1,827.10%",
          "val2": "-21,204.60%",
          "chgp": "1,937.75%",
          "chgp_class": "positive"
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    "link": "annual",
    "btn_text": "All Annual Results",
    "header": "Annual Results Snapshot (Consolidated) - Dec'24",
    "rhs": [
      {
        "prefix": "Net Sales ",
        "suffix": "YoY Growth in year ended Dec 2024 is 0.00% vs 0.00% in Dec 2023",
        "dir": 0
      },
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        "prefix": "Consolidated Net Profit ",
        "suffix": "YoY Growth in year ended Dec 2024 is -52.24% vs -40.25% in Dec 2023",
        "dir": -1
      }
    ],
    "table": {
      "header": [
        "Dec'24",
        "Dec'23",
        "Change(%)"
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          "val2": "0.00",
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          "field": "Interest",
          "val1": "4.90",
          "val2": "0.20",
          "chgp": "2,350.00%",
          "chgp_class": "negative"
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        {
          "field": "Exceptional Items",
          "val1": "0.00",
          "val2": "0.00",
          "chgp": "",
          "chgp_class": "neutral"
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          "field": "Consolidate Net Profit",
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          "field": "Operating Profit Margin (Excl OI)",
          "val1": "-14,344.30%",
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Quarterly Results Snapshot (Consolidated) - Jun'25 - YoYstock-summary
Jun'25
Jun'24
Change(%)
Net Sales
38.00
3.50
985.71%
Operating Profit (PBDIT) excl Other Income
-69.40
-74.20
6.47%
Interest
7.90
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-71.80
-68.10
-5.43%
Operating Profit Margin (Excl OI)
-1,827.10%
-21,204.60%
1,937.75%
USD in Million.
Direction Arrows
Net Sales

YoY Growth in quarter ended Jun 2025 is 985.71% vs 0.00% in Jun 2024

Direction Arrows
Consolidated Net Profit

YoY Growth in quarter ended Jun 2025 is -5.43% vs -52.69% in Jun 2024

Annual Results Snapshot (Consolidated) - Dec'24stock-summary
Dec'24
Dec'23
Change(%)
Net Sales
23.70
0.00
Operating Profit (PBDIT) excl Other Income
-339.70
-229.90
-47.76%
Interest
4.90
0.20
2,350.00%
Exceptional Items
0.00
0.00
Consolidate Net Profit
-318.80
-209.40
-52.24%
Operating Profit Margin (Excl OI)
-14,344.30%
0.00%
-1,434.43%
USD in Million.
Net Sales

YoY Growth in year ended Dec 2024 is 0.00% vs 0.00% in Dec 2023

Direction Arrows
Consolidated Net Profit

YoY Growth in year ended Dec 2024 is -52.24% vs -40.25% in Dec 2023

stock-summaryCompany CV
About Syndax Pharmaceuticals, Inc. stock-summary
stock-summary
Syndax Pharmaceuticals, Inc.
Pharmaceuticals & Biotechnology
Syndax Pharmaceuticals, Inc. is a clinical stage biopharmaceutical company focused on developing a pipeline of combination therapies in multiple cancer indications. The Company’s product candidate, entinostat, is a once-weekly, oral, small molecule, Class I histone deacetylases (HDAC) inhibitor that being evaluated in the Phase III E2112 registrational clinical trial in combination with exemestane for hormone receptor positive, human epidermal growth factor receptor 2 negative, and breast cancer. The Company’s clinical-stage product candidate, SNDX-5613, is the orally available, small molecule inhibitor of the interaction of menin with the mixed lineage leukemia protein (MLL). It is developing SNDX-5613 as a targeted therapy to treat two genetically defined acute leukemias: mixed lineage leukemia-rearranged (MLLr), and acute myeloid leukemia (AML), with a mutated nucleophosmin 1. It is also developing SNDX-6352, a monoclonal antibody targeting the colony stimulating factor-1 receptor.
Company Coordinates stock-summary
Company Details
Building D, 35 Gatehouse Dr Fl 3 , WALTHAM MA : 02451-1215
stock-summary
Tel: 1 781 4191400
stock-summary
Registrar Details