Protagonist Therapeutics, Inc.

  • Market Cap: Small Cap
  • Industry: Pharmaceuticals & Biotechnology
  • ISIN: US74366E1029
USD
96.48
-0.57 (-0.59%)
  • Price Points
  • Score
  • Mojo Parameters
  • Total Return
  • News and Corporate Actions
  • Key factors
  • Shareholding
  • Financials
  • CompanyCV
stock-summaryPrice Point
High/Low

1Day

52 Week

Valuation
Technical
Day's Volume

CASH

788.74 k

Shareholding (Dec 2025)

FII

19.66%

Held by 156 FIIs

DII

33.94%

Held by 53 DIIs

Promoter

4.47%

How big is Protagonist Therapeutics, Inc.?

22-Jun-2025

As of Jun 18, Protagonist Therapeutics, Inc. has a market capitalization of $3.42 billion, with net sales of $207.80 million and a net profit of $56.19 million over the last four quarters. As of Dec 24, shareholder's funds are $675.29 million, and total assets are $746.83 million.

As of Jun 18, Protagonist Therapeutics, Inc. has a market capitalization of 3,422.02 million, categorizing it as a Micro Cap company.<BR><BR>As of Jun 18, the sum of net sales for the latest four quarters is 207.80 million, while the sum of net profit for the same period is 56.19 million.<BR><BR>As of Dec 24, the shareholder's funds are reported at 675.29 million, and total assets amount to 746.83 million.

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What does Protagonist Therapeutics, Inc. do?

22-Jun-2025

Protagonist Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new therapies for unmet medical needs. As of March 2025, it reported net sales of $28 million and a net loss of $12 million, with a market cap of approximately $3.42 billion.

Overview: <BR>Protagonist Therapeutics, Inc. is a clinical-stage biopharmaceutical company in the Pharmaceuticals & Biotechnology industry, focused on discovering and developing new chemical entities to address significant unmet medical needs.<BR><BR>Financial Snapshot: <BR>Net Sales: 28 Million (Quarterly Results - Mar 2025) <BR>Net Profit: -12 Million (Quarterly Results - Mar 2025) <BR>Market cap: USD 3,422.02 Million (Micro Cap) <BR><BR>Key Metrics: <BR>P/E: 60.00 <BR>Dividend Yield: 0.00% <BR>Debt Equity: -0.83 <BR>Return on Equity: 8.16% <BR>Price to Book: 4.97 <BR><BR>Contact Details: <BR>Address: 7707 Gateway Blvd Ste 140, NEWARK CA: 94560-1160 <BR>Tel: ['1 510 4740170', '1 646 3782923'] <BR>Fax: 1 302 6365454 <BR>Website: http://www.protagonist-inc.com/

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Should I buy, sell or hold Protagonist Therapeutics, Inc.?

22-Jun-2025

Who are in the management team of Protagonist Therapeutics, Inc.?

22-Jun-2025

As of March 2022, the management team of Protagonist Therapeutics, Inc. includes Dr. Harold Selick (Independent Chairman), Dr. Dinesh Patel (President and CEO), and several Independent Directors: Mr. Bryan Giraudo, Dr. Sarah Noonberg, Ms. Sarah O'Dowd, Mr. William Waddill, and Dr. Lewis Williams. They oversee the company's strategic direction and operations.

As of March 2022, the management team of Protagonist Therapeutics, Inc. includes the following individuals:<BR><BR>- Dr. Harold Selick, who serves as the Independent Chairman of the Board.<BR>- Dr. Dinesh Patel, who is the President, Chief Executive Officer, and a Director.<BR>- Mr. Bryan Giraudo, an Independent Director.<BR>- Dr. Sarah Noonberg, an Independent Director.<BR>- Ms. Sarah O'Dowd, an Independent Director.<BR>- Mr. William Waddill, an Independent Director.<BR>- Dr. Lewis Williams, an Independent Director.<BR><BR>This team is responsible for guiding the strategic direction and operations of the company.

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Is Protagonist Therapeutics, Inc. technically bullish or bearish?

07-Oct-2025

As of October 3, 2025, Protagonist Therapeutics, Inc. has a mildly bullish technical trend, supported by bullish MACD and moving averages, despite some bearish signals from the RSI and KST, and has significantly outperformed the S&P 500 year-to-date and over the past year.

As of 3 October 2025, the technical trend for Protagonist Therapeutics, Inc. has changed from bullish to mildly bullish. The weekly MACD remains bullish, while the monthly MACD is also bullish. The daily moving averages indicate a bullish stance. However, the monthly RSI shows a bearish signal, and the KST is mildly bearish on a monthly basis. Bollinger Bands are mildly bullish on both weekly and monthly time frames. Dow Theory and OBV show no trend in either time frame.<BR><BR>In terms of performance, Protagonist Therapeutics has outperformed the S&P 500 year-to-date with a return of 66.17% compared to 14.18%, and over the past year with a return of 44.56% versus 17.82%. Overall, the current technical stance is mildly bullish, driven primarily by the bullish MACD and moving averages, despite some bearish signals from the RSI and KST.

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Is Protagonist Therapeutics, Inc. overvalued or undervalued?

21-Oct-2025

As of October 17, 2025, Protagonist Therapeutics, Inc. is considered very expensive and overvalued due to high valuation ratios, including a P/E of 60 and an EV to EBITDA of 94.50, especially when compared to peers like Aurinia Pharmaceuticals, which has a P/E of 20.87.

As of 17 October 2025, the valuation grade for Protagonist Therapeutics, Inc. moved from expensive to very expensive. The company appears to be overvalued based on its high valuation ratios, including a P/E ratio of 60, an EV to EBITDA of 94.50, and a Price to Book Value of 4.89. In comparison, Aurinia Pharmaceuticals, Inc. has a more reasonable P/E ratio of 20.87 and an EV to EBITDA of 12.92, indicating that Protagonist is trading at a significant premium relative to its peers.<BR><BR>Despite a strong year-to-date return of 100.78% compared to the S&P 500's 13.30%, the high valuation metrics suggest that the stock may not be sustainable at its current levels. The substantial disparity in valuation ratios, particularly when compared to its peers, reinforces the conclusion that Protagonist Therapeutics is overvalued.

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iScoreScore
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Strong Sell
Sell
Hold
Buy
Strong Buy

Dashboard

1

Poor Management Efficiency with a low ROE of 7.42%

  • The company has been able to generate a Return on Equity (avg) of 7.42% signifying low profitability per unit of shareholders funds
2

With a fall in Net Sales of -85.78%, the company declared Very Negative results in Sep 25

3

Risky -

stock-summaryMojo Parameters

Mojo Parameters

Stock DNA

stock-summary
Industry

Pharmaceuticals & Biotechnology

stock-summary
Market cap

USD 5,174 Million (Small Cap)

stock-summary
P/E

92.00

stock-summary
Industry P/E

NA

stock-summary
Dividend Yield

0.00%

stock-summary
Debt Equity

-0.89

stock-summary
Return on Equity

7.11%

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Price to Book

8.02

Revenue and Profits:
Net Sales:
7 Million
(Quarterly Results - Dec 2025)
Net Profit:
-44 Million
stock-summaryTotal Returns
Total Returns (Price + Dividend) stock-summary
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
4.59%
0%
4.59%
6 Months
61.66%
0%
61.66%
1 Year
61.45%
0%
61.45%
2 Years
220.32%
0%
220.32%
3 Years
285.92%
0%
285.92%
4 Years
278.2%
0%
278.2%
5 Years
210.72%
0%
210.72%

Protagonist Therapeutics, Inc. for the last several years.

Risk Adjusted Returns v/s stock-summary
stock-summaryNews & Corporate Actions

News

Icon
No Recent News for the Company

Announcements stock-summary

Icon
No announcement available

Corporate Actions stock-summary

Icon
No corporate action available
stock-summaryKey Factors

Quality key factors stock-summary

Factor
Value
Sales Growth (5y)
52.10%
EBIT Growth (5y)
18.10%
EBIT to Interest (avg)
-33.21
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-0.83
Sales to Capital Employed (avg)
0.44
Tax Ratio
1.57%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
17.16%
ROE (avg)
7.42%

Valuation key factors

Factor
Value
P/E Ratio
92
Industry P/E
Price to Book Value
7.14
EV to EBIT
175.37
EV to EBITDA
163.16
EV to Capital Employed
42.16
EV to Sales
20.10
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
24.04%
ROE (Latest)
7.79%

Technicals key factors

Indicator
Weekly
Monthly
MACD
Bullish
Bullish
RSI
No Signal
Bearish
Bollinger Bands
Bullish
Bullish
Moving Averages
Bullish (Daily)
KST
Mildly Bearish
Bullish
Dow Theory
Bullish
Bullish
OBV
Bullish
Bullish
stock-summary Technical Indicator Scale: Bearish, Mildly Bearish, Sideways, Mildly Bullish, Bullish  Turned 
stock-summaryShareholding
Shareholding Snapshot : Dec 2025stock-summary
Shareholding Compare (%holding) stock-summary
Majority shareholders

Domestic Funds

Domestic Funds

Held in 73 Schemes (41.86%)

Foreign Institutions

Held by 156 Foreign Institutions (19.66%)

Strategic Entities with highest holding

Highest Public shareholder

stock-summaryFinancial
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    "header": "Quarterly Results Snapshot (Consolidated) - Dec'25 - QoQ",
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          "field": "Consolidate Net Profit",
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          "val2": "-39.30",
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          "chgp_class": "negative"
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        {
          "field": "Operating Profit Margin (Excl OI)",
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Quarterly Results Snapshot (Consolidated) - Dec'25 - QoQstock-summary

Dec'25
Sep'25
Change(%)
Net Sales
7.40
4.70
57.45%
Operating Profit (PBDIT) excl Other Income
-50.00
-46.10
-8.46%
Interest
0.00
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-44.40
-39.30
-12.98%
Operating Profit Margin (Excl OI)
-6,770.90%
-9,851.70%
308.08%
USD in Million.
Direction Arrows
Net Sales

QoQ Growth in quarter ended Dec 2025 is 57.45% vs -14.55% in Sep 2025

Direction Arrows
Consolidated Net Profit

QoQ Growth in quarter ended Dec 2025 is -12.98% vs -12.93% in Sep 2025

Annual Results Snapshot (Consolidated) - Dec'25stock-summary

Dec'25
Dec'24
Change(%)
Net Sales
46.00
434.40
-89.41%
Operating Profit (PBDIT) excl Other Income
-156.90
255.80
-161.34%
Interest
0.00
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-130.10
275.20
-147.27%
Operating Profit Margin (Excl OI)
-3,436.30%
582.00%
-401.83%
USD in Million.
Direction Arrows
Net Sales

YoY Growth in year ended Dec 2025 is -89.41% vs 624.00% in Dec 2024

Direction Arrows
Consolidated Net Profit

YoY Growth in year ended Dec 2025 is -147.27% vs 448.35% in Dec 2024

stock-summaryCompany CV
About Protagonist Therapeutics, Inc. stock-summary
stock-summary
Protagonist Therapeutics, Inc.
Pharmaceuticals & Biotechnology
Protagonist Therapeutics, Inc. is a clinical-stage biopharmaceutical company with a peptide technology platform focused on discovering and developing new chemical entities (NECs) to address significant unmet medical needs. The Company's product pipeline includes PTG-100, PTG-200 and PTG-300. Its primary focus is on developing oral peptide drugs that target biological pathways also targeted by marketed injectable antibody drugs. PTG-100 is an oral, alpha-4-beta-7 (a4b7) integrin-specific antagonist peptide product candidate, which has completed a Phase I clinical trial in normal healthy volunteers (NHVs). PTG-100 is being developed for treatment of moderate-to-severe ulcerative colitis (UC). PTG-200 is an oral Interleukin-23 receptor (IL-23R) antagonist being developed for moderate-to-severe Crohn's disease (CD). PTG-200 is in investigational new drug (IND) enabling studies. PTG-300 is an injectable hepcidin mimetic for treatment of iron overload related rare diseases.
Company Coordinates stock-summary
Company Details
7707 Gateway Blvd Ste 140 , NEWARK CA : 94560-1160
stock-summary
Tel: 1 510 47401701 646 3782923
stock-summary
Registrar Details