Compare Protagonist Therapeutics, Inc. with Similar Stocks
Stock DNA
Pharmaceuticals & Biotechnology
USD 6,173 Million (Small Cap)
134.00
NA
0.00%
-0.89
7.11%
9.56
Revenue and Profits:
Net Sales:
7 Million
(Quarterly Results - Dec 2025)
Net Profit:
-44 Million
Total Returns (Price + Dividend) 
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
20.34%
0%
20.34%
6 Months
33.58%
0%
33.58%
1 Year
122.97%
0%
122.97%
2 Years
289.11%
0%
289.11%
3 Years
321.05%
0%
321.05%
4 Years
428.82%
0%
428.82%
5 Years
244.0%
0%
244.0%
Protagonist Therapeutics, Inc. for the last several years.
Risk Adjusted Returns v/s 
News
No Recent News for the Company
Announcements 
No announcement available
Corporate Actions 
No corporate action available
Quality key factors 
Factor
Value
Sales Growth (5y)
52.10%
EBIT Growth (5y)
18.10%
EBIT to Interest (avg)
-33.21
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-0.83
Sales to Capital Employed (avg)
0.44
Tax Ratio
1.57%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
17.16%
ROE (avg)
7.42%
Valuation key factors
Factor
Value
P/E Ratio
134
Industry P/E
Price to Book Value
9.56
EV to EBIT
294.59
EV to EBITDA
272.94
EV to Capital Employed
78.26
EV to Sales
26.76
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
26.57%
ROE (Latest)
7.11%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Bullish
Bullish
RSI
No Signal
Bearish
Bollinger Bands
Bullish
Bullish
Moving Averages
Bullish (Daily)
KST
Bullish
Bullish
Dow Theory
Mildly Bullish
Bullish
OBV
Mildly Bullish
No Trend
Shareholding Snapshot : Dec 2025
Shareholding Compare (%holding) 
Majority shareholders
Domestic Funds
Domestic Funds
Held in 73 Schemes (41.86%)
Foreign Institutions
Held by 156 Foreign Institutions (19.66%)
Strategic Entities with highest holding
Highest Public shareholder
Quarterly Results Snapshot (Consolidated) - Dec'25 - QoQ
Dec'25
Sep'25
Change(%)
Net Sales
7.40
4.70
57.45%
Operating Profit (PBDIT) excl Other Income
-50.00
-46.10
-8.46%
Interest
0.00
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-44.40
-39.30
-12.98%
Operating Profit Margin (Excl OI)
-6,770.90%
-9,851.70%
308.08%
USD in Million.
Net Sales
QoQ Growth in quarter ended Dec 2025 is 57.45% vs -14.55% in Sep 2025
Consolidated Net Profit
QoQ Growth in quarter ended Dec 2025 is -12.98% vs -12.93% in Sep 2025
Annual Results Snapshot (Consolidated) - Dec'25
Dec'25
Dec'24
Change(%)
Net Sales
46.00
434.40
-89.41%
Operating Profit (PBDIT) excl Other Income
-156.90
255.80
-161.34%
Interest
0.00
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-130.10
275.20
-147.27%
Operating Profit Margin (Excl OI)
-3,436.30%
582.00%
-401.83%
USD in Million.
Net Sales
YoY Growth in year ended Dec 2025 is -89.41% vs 624.00% in Dec 2024
Consolidated Net Profit
YoY Growth in year ended Dec 2025 is -147.27% vs 448.35% in Dec 2024
About Protagonist Therapeutics, Inc. 
Protagonist Therapeutics, Inc.
Pharmaceuticals & Biotechnology
Protagonist Therapeutics, Inc. is a clinical-stage biopharmaceutical company with a peptide technology platform focused on discovering and developing new chemical entities (NECs) to address significant unmet medical needs. The Company's product pipeline includes PTG-100, PTG-200 and PTG-300. Its primary focus is on developing oral peptide drugs that target biological pathways also targeted by marketed injectable antibody drugs. PTG-100 is an oral, alpha-4-beta-7 (a4b7) integrin-specific antagonist peptide product candidate, which has completed a Phase I clinical trial in normal healthy volunteers (NHVs). PTG-100 is being developed for treatment of moderate-to-severe ulcerative colitis (UC). PTG-200 is an oral Interleukin-23 receptor (IL-23R) antagonist being developed for moderate-to-severe Crohn's disease (CD). PTG-200 is in investigational new drug (IND) enabling studies. PTG-300 is an injectable hepcidin mimetic for treatment of iron overload related rare diseases.
Company Coordinates 
Company Details
7707 Gateway Blvd Ste 140 , NEWARK CA : 94560-1160
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