Compare Agios Pharmaceuticals, Inc. with Similar Stocks
Dashboard
1
Poor Management Efficiency with a low ROE of 9.08%
- The company has been able to generate a Return on Equity (avg) of 9.08% signifying low profitability per unit of shareholders funds
2
Poor long term growth as Net Sales has grown by an annual rate of -23.27% and Operating profit at -12.72% over the last 5 years
3
Positive results in Dec 25
4
Risky -
5
Rising Promoter Confidence
6
Consistent Underperformance against the benchmark over the last 3 years
Stock DNA
Pharmaceuticals & Biotechnology
USD 2,145 Million (Small Cap)
NA (Loss Making)
NA
0.00%
-0.70
-34.60%
1.80
Revenue and Profits:
Net Sales:
20 Million
(Quarterly Results - Dec 2025)
Net Profit:
-108 Million
Total Returns (Price + Dividend) 
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
13.67%
0%
13.67%
6 Months
-25.93%
0%
-25.93%
1 Year
-9.9%
0%
-9.9%
2 Years
-4.03%
0%
-4.03%
3 Years
20.85%
0%
20.85%
4 Years
-4.68%
0%
-4.68%
5 Years
-42.09%
0%
-42.09%
Agios Pharmaceuticals, Inc. for the last several years.
Risk Adjusted Returns v/s 
News
No Recent News for the Company
Announcements 
No announcement available
Corporate Actions 
No corporate action available
Quality key factors 
Factor
Value
Sales Growth (5y)
-23.27%
EBIT Growth (5y)
-12.72%
EBIT to Interest (avg)
-324.10
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-0.60
Sales to Capital Employed (avg)
0.03
Tax Ratio
6.23%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
0
ROE (avg)
9.08%
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
1.80
EV to EBIT
-2.77
EV to EBITDA
-2.80
EV to Capital Employed
3.67
EV to Sales
24.24
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
-132.22%
ROE (Latest)
-34.60%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Mildly Bullish
Bearish
RSI
No Signal
Bullish
Bollinger Bands
Mildly Bearish
Bearish
Moving Averages
Bearish (Daily)
KST
Mildly Bullish
Bearish
Dow Theory
Mildly Bearish
No Trend
OBV
Mildly Bearish
No Trend
Shareholding Snapshot : Dec 2025
Shareholding Compare (%holding) 
Majority shareholders
Domestic Funds
Domestic Funds
Held in 60 Schemes (34.39%)
Foreign Institutions
Held by 110 Foreign Institutions (25.62%)
Strategic Entities with highest holding
Highest Public shareholder
Quarterly Results Snapshot (Consolidated) - Dec'25 - QoQ
Dec'25
Sep'25
Change(%)
Net Sales
20.00
12.90
55.04%
Operating Profit (PBDIT) excl Other Income
-120.30
-115.50
-4.16%
Interest
0.00
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-108.00
-103.40
-4.45%
Operating Profit Margin (Excl OI)
-6,088.90%
-9,073.70%
298.48%
USD in Million.
Net Sales
QoQ Growth in quarter ended Dec 2025 is 55.04% vs 3.20% in Sep 2025
Consolidated Net Profit
QoQ Growth in quarter ended Dec 2025 is -4.45% vs 7.68% in Sep 2025
Annual Results Snapshot (Consolidated) - Dec'25
Dec'25
Dec'24
Change(%)
Net Sales
54.00
36.50
47.95%
Operating Profit (PBDIT) excl Other Income
-467.00
-420.10
-11.16%
Interest
0.00
0.00
Exceptional Items
0.00
0.00
Consolidate Net Profit
-412.80
673.70
-161.27%
Operating Profit Margin (Excl OI)
-8,738.70%
-11,664.70%
292.60%
USD in Million.
Net Sales
YoY Growth in year ended Dec 2025 is 47.95% vs 36.19% in Dec 2024
Consolidated Net Profit
YoY Growth in year ended Dec 2025 is -161.27% vs 291.34% in Dec 2024
About Agios Pharmaceuticals, Inc. 
Agios Pharmaceuticals, Inc.
Pharmaceuticals & Biotechnology
Agios Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company's therapeutic areas of focus are cancer and rare genetic metabolic disorders, which are a group of over 600 rare genetic diseases caused by mutations, or defects, of single metabolic genes. The Company's cancer product candidates are enasidenib and ivosidenib (AG-120), which target mutated isocitrate dehydrogenase 2 (IDH2) and isocitrate dehydrogenase 1 (IDH1), respectively, and AG-881, which targets both mutated IDH1 and mutated IDH2. These mutations are found in a range of hematological malignancies and solid tumors. The lead product candidate in its rare genetic metabolic disorder (RGD), programs, AG-348, targets pyruvate kinase-R for the treatment of pyruvate kinase deficiency. Pyruvate kinase deficiency is a rare disorder that often results in severe hemolytic anemia due to inherited mutations in the pyruvate kinase enzyme within red blood cells.
Company Coordinates 
Company Details
88 Sidney St , CAMBRIDGE MA : 02139-4137
Registrar Details






