Apellis Pharmaceuticals, Inc.

  • Market Cap: Small Cap
  • Industry: Pharmaceuticals & Biotechnology
  • ISIN: US03753U1060
USD
22.19
1.53 (7.41%)
  • Price Points
  • Score
  • Mojo Parameters
  • Total Return
  • News and Corporate Actions
  • Key factors
  • Shareholding
  • Financials
  • CompanyCV
stock-summaryPrice Point
High/Low

1Day

52 Week

Valuation
Technical
Day's Volume

CASH

2.56 M

Shareholding (Mar 2025)

FII

19.86%

Held by 177 FIIs

DII

30.49%

Held by 61 DIIs

Promoter

5.49%

How big is Apellis Pharmaceuticals, Inc.?

22-Jun-2025

As of Jun 18, Apellis Pharmaceuticals, Inc. has a market capitalization of $2.23 billion, with net sales of $775.85 million and a net profit of -$223.68 million over the latest four quarters.

Market Cap: As of Jun 18, Apellis Pharmaceuticals, Inc. has a market capitalization of 2,232.12 million, classifying it as a Mid Cap company.<BR><BR>Recent Quarterly Performance: For the latest four quarters, Apellis Pharmaceuticals, Inc. reported net sales of 775.85 million and a net profit of -223.68 million.<BR><BR>Balance Sheet Snapshot: As of Dec 24, the company reported shareholder's funds of 228.54 million and total assets of 885.05 million.

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What does Apellis Pharmaceuticals, Inc. do?

22-Jun-2025

Apellis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on developing therapies for autoimmune and inflammatory diseases. As of March 2025, it has a market cap of approximately $2.23 billion, with net sales of $167 million and a net loss of $92 million.

Overview: <BR>Apellis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company focused on the discovery and development of therapeutic compounds for autoimmune and inflammatory diseases, operating within the Pharmaceuticals & Biotechnology industry and classified as a mid-cap company.<BR><BR>Financial Snapshot: <BR>Net Sales: 167 Million (Quarterly Results - Mar 2025) <BR>Net Profit: -92 Million (Quarterly Results - Mar 2025) <BR>Market cap: USD 2,232.12 Million (Mid Cap)<BR><BR>Key Metrics: <BR>P/E: NA (Loss Making) <BR>Industry P/E: NA <BR>Dividend Yield: 0.00% <BR>Debt Equity: 0.61 <BR>Return on Equity: -135.02% <BR>Price to Book: 13.59<BR><BR>Contact Details: <BR>Address: 100 5th Avenue, WALTHAM MA : 02451 <BR>Tel: ['1 617 9775700', '1 212 6001902'] <BR>Fax: 1 302 6555049 <BR>Website: http://apellis.com/

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Should I buy, sell or hold Apellis Pharmaceuticals, Inc.?

22-Jun-2025

Who are in the management team of Apellis Pharmaceuticals, Inc.?

22-Jun-2025

As of March 2022, the management team of Apellis Pharmaceuticals, Inc. includes Dr. Cedric Francois as CEO and several independent directors, including Dr. Gerald Chan (Chairman), Mr. A. Sinclair Dunlop, Mr. Paul Fonteyne, Mr. Alec Machiels, and Ms. Stephanie O'Brien.

As of March 2022, the management team of Apellis Pharmaceuticals, Inc. includes the following individuals:<BR><BR>- Dr. Gerald Chan, who serves as the Independent Chairman of the Board.<BR>- Dr. Cedric Francois, who is the President, Chief Executive Officer, Co-Founder, and Director.<BR>- Mr. A. Sinclair Dunlop, who is an Independent Director.<BR>- Mr. Paul Fonteyne, who is an Independent Director.<BR>- Mr. Alec Machiels, who is an Independent Director.<BR>- Ms. Stephanie O'Brien, who is an Independent Director.<BR><BR>In summary, the management team consists of a mix of executive leadership and independent directors, with Dr. Cedric Francois leading as the CEO.

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Is Apellis Pharmaceuticals, Inc. overvalued or undervalued?

20-Sep-2025

As of February 25, 2021, Apellis Pharmaceuticals is considered risky and overvalued due to high valuation ratios and poor performance, including a YTD return of -26.73% and an ROE of -135.02%.

As of 25 February 2021, the valuation grade for Apellis Pharmaceuticals, Inc. has moved from does not qualify to risky, indicating increased caution for investors. The company appears to be overvalued, given its negative valuation ratios, including a Price to Book Value of 14.76 and an EV to Sales ratio of 3.25, which are significantly higher than many of its peers. Notably, Exelixis, Inc. has a P/E ratio of 15.81 and an EV to EBITDA of 11.97, showcasing a more favorable valuation profile.<BR><BR>The company's recent performance has been concerning, with a YTD return of -26.73% compared to the S&P 500's 12.22%, highlighting a stark underperformance. Additionally, the ROE stands at -135.02%, further emphasizing the challenges Apellis faces in generating returns for shareholders. Overall, the combination of high valuation ratios and poor stock performance suggests that Apellis Pharmaceuticals is overvalued in the current market context.

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Is Apellis Pharmaceuticals, Inc. technically bullish or bearish?

05-Nov-2025

As of October 31, 2025, Apellis Pharmaceuticals has shifted to a neutral technical stance with mixed signals, showing a year-to-date return of -35.85%, significantly underperforming the S&P 500's 16.30%.

As of 31 October 2025, the technical trend for Apellis Pharmaceuticals, Inc. has changed from bullish to sideways. The current technical stance is neutral, with mixed signals across various indicators. The weekly MACD is mildly bearish, while the monthly MACD is mildly bullish. The weekly RSI shows no signal, but the monthly RSI is bearish. Bollinger Bands indicate bearish conditions for both weekly and monthly periods. Daily moving averages are mildly bullish, but the KST and Dow Theory show no trend on both weekly and monthly time frames. <BR><BR>In terms of performance, the stock has underperformed significantly against the S&P 500 across multiple periods, with a year-to-date return of -35.85% compared to the S&P 500's 16.30%, and a one-year return of -26.84% against 19.89% for the benchmark.

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iScoreScore
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Strong Sell
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Strong Buy

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Dashboard
1

With a growth in Operating Profit of 16.68%, the company declared Outstanding results in Jun 25

  • OPERATING CASH FLOW(Y) Highest at USD 4.49 MM
  • NET PROFIT(HY) Higher at USD -134.38 MM
  • RAW MATERIAL COST(Y) Fallen by -4.48% (YoY)
2

With ROE of -135.02%, it has a risky valuation with a 14.76 Price to Book Value

3

High Institutional Holdings at 100%

stock-summaryMojo Parameters
Mojo Parameters
Stock DNA
stock-summary
Industry

Pharmaceuticals & Biotechnology

stock-summary
Market cap

USD 3,398 Million (Small Cap)

stock-summary
P/E

NA (Loss Making)

stock-summary
Industry P/E

NA

stock-summary
Dividend Yield

0.00%

stock-summary
Debt Equity

0.58

stock-summary
Return on Equity

-145.98%

stock-summary
Price to Book

21.74

Revenue and Profits:
Net Sales:
178 Million
(Quarterly Results - Jun 2025)
Net Profit:
-42 Million
stock-summaryTotal Returns
Total Returns (Price + Dividend) stock-summary
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
-20.18%
0%
-20.18%
6 Months
17.91%
0%
17.91%
1 Year
-35.92%
0%
-35.92%
2 Years
-63.97%
0%
-63.97%
3 Years
-56.17%
0%
-56.17%
4 Years
-46.79%
0%
-46.79%
5 Years
-53.3%
0%
-53.3%

Apellis Pharmaceuticals, Inc. for the last several years.

Risk Adjusted Returns v/s stock-summary
stock-summaryNews & Corporate Actions
News
Announcements stock-summary
Icon
No announcement available
Corporate Actions stock-summary
Icon
No corporate action available
stock-summaryKey Factors
Quality key factors stock-summary
Factor
Value
Sales Growth (5y)
276.41%
EBIT Growth (5y)
8.63%
EBIT to Interest (avg)
-15.40
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
0.61
Sales to Capital Employed (avg)
0.84
Tax Ratio
0.60%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
0
ROE (avg)
0
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
14.76
EV to EBIT
-13.55
EV to EBITDA
-13.68
EV to Capital Employed
9.53
EV to Sales
3.25
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
-70.33%
ROE (Latest)
-135.02%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Bearish
Mildly Bullish
RSI
No Signal
Bearish
Bollinger Bands
Mildly Bearish
Bearish
Moving Averages
Mildly Bullish (Daily)
KST
Mildly Bearish
Bearish
Dow Theory
Mildly Bearish
Mildly Bearish
OBV
Mildly Bearish
Mildly Bearish
stock-summary Technical Indicator Scale: Bearish, Mildly Bearish, Sideways, Mildly Bullish, Bullish  Turned 
stock-summaryShareholding
Shareholding Snapshot : Mar 2025stock-summary
Shareholding Compare (%holding) stock-summary
Majority shareholders

Domestic Funds

Domestic Funds

Held in 92 Schemes (44.12%)

Foreign Institutions

Held by 177 Foreign Institutions (19.86%)

Strategic Entities with highest holding

Highest Public shareholder

stock-summaryFinancial
[
  {
    "link": "quarterly",
    "btn_text": "All Quarterly Results",
    "header": "Quarterly Results Snapshot (Consolidated) - Jun'25 - YoY",
    "rhs": [
      {
        "prefix": "Net Sales ",
        "suffix": "YoY Growth in quarter ended Jun 2025 is -10.62% vs 110.21% in Jun 2024",
        "dir": -1
      },
      {
        "prefix": "Consolidated Net Profit ",
        "suffix": "YoY Growth in quarter ended Jun 2025 is -11.94% vs 69.10% in Jun 2024",
        "dir": -1
      }
    ],
    "table": {
      "header": [
        "Jun'25",
        "Jun'24",
        "Change(%)"
      ],
      "body": [
        {
          "field": "Net Sales",
          "val1": "178.50",
          "val2": "199.70",
          "chgp": "-10.62%",
          "chgp_class": "negative"
        },
        {
          "field": "Operating Profit (PBDIT) excl Other Income",
          "val1": "-32.80",
          "val2": "-29.00",
          "chgp": "-13.10%",
          "chgp_class": "negative"
        },
        {
          "field": "Interest",
          "val1": "11.20",
          "val2": "9.40",
          "chgp": "19.15%",
          "chgp_class": "negative"
        },
        {
          "field": "Exceptional Items",
          "val1": "0.00",
          "val2": "-1.90",
          "chgp": "100.00%",
          "chgp_class": "positive"
        },
        {
          "field": "Consolidate Net Profit",
          "val1": "-42.20",
          "val2": "-37.70",
          "chgp": "-11.94%",
          "chgp_class": "negative"
        },
        {
          "field": "Operating Profit Margin (Excl OI)",
          "val1": "-186.50%",
          "val2": "-147.40%",
          "chgp": "-3.91%",
          "chgp_class": "negative"
        }
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    }
  },
  {
    "link": "annual",
    "btn_text": "All Annual Results",
    "header": "Annual Results Snapshot (Consolidated) - Dec'24",
    "rhs": [
      {
        "prefix": "Net Sales ",
        "suffix": "YoY Growth in year ended Dec 2024 is 97.02% vs 425.99% in Dec 2023",
        "dir": -1
      },
      {
        "prefix": "Consolidated Net Profit ",
        "suffix": "YoY Growth in year ended Dec 2024 is 62.56% vs 18.95% in Dec 2023",
        "dir": 1
      }
    ],
    "table": {
      "header": [
        "Dec'24",
        "Dec'23",
        "Change(%)"
      ],
      "body": [
        {
          "field": "Net Sales",
          "val1": "781.40",
          "val2": "396.60",
          "chgp": "97.02%",
          "chgp_class": "positive"
        },
        {
          "field": "Operating Profit (PBDIT) excl Other Income",
          "val1": "-163.20",
          "val2": "-515.40",
          "chgp": "68.34%",
          "chgp_class": "positive"
        },
        {
          "field": "Interest",
          "val1": "40.40",
          "val2": "29.60",
          "chgp": "36.49%",
          "chgp_class": "negative"
        },
        {
          "field": "Exceptional Items",
          "val1": "-1.90",
          "val2": "0.00",
          "chgp": "",
          "chgp_class": "neutral"
        },
        {
          "field": "Consolidate Net Profit",
          "val1": "-197.90",
          "val2": "-528.60",
          "chgp": "62.56%",
          "chgp_class": "positive"
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        {
          "field": "Operating Profit Margin (Excl OI)",
          "val1": "-211.10%",
          "val2": "-1,303.90%",
          "chgp": "109.28%",
          "chgp_class": "positive"
        }
      ]
    }
  }
]
Quarterly Results Snapshot (Consolidated) - Jun'25 - YoYstock-summary
Jun'25
Jun'24
Change(%)
Net Sales
178.50
199.70
-10.62%
Operating Profit (PBDIT) excl Other Income
-32.80
-29.00
-13.10%
Interest
11.20
9.40
19.15%
Exceptional Items
0.00
-1.90
100.00%
Consolidate Net Profit
-42.20
-37.70
-11.94%
Operating Profit Margin (Excl OI)
-186.50%
-147.40%
-3.91%
USD in Million.
Direction Arrows
Net Sales

YoY Growth in quarter ended Jun 2025 is -10.62% vs 110.21% in Jun 2024

Direction Arrows
Consolidated Net Profit

YoY Growth in quarter ended Jun 2025 is -11.94% vs 69.10% in Jun 2024

Annual Results Snapshot (Consolidated) - Dec'24stock-summary
Dec'24
Dec'23
Change(%)
Net Sales
781.40
396.60
97.02%
Operating Profit (PBDIT) excl Other Income
-163.20
-515.40
68.34%
Interest
40.40
29.60
36.49%
Exceptional Items
-1.90
0.00
Consolidate Net Profit
-197.90
-528.60
62.56%
Operating Profit Margin (Excl OI)
-211.10%
-1,303.90%
109.28%
USD in Million.
Direction Arrows
Net Sales

YoY Growth in year ended Dec 2024 is 97.02% vs 425.99% in Dec 2023

Direction Arrows
Consolidated Net Profit

YoY Growth in year ended Dec 2024 is 62.56% vs 18.95% in Dec 2023

stock-summaryCompany CV
About Apellis Pharmaceuticals, Inc. stock-summary
stock-summary
Apellis Pharmaceuticals, Inc.
Pharmaceuticals & Biotechnology
Apellis Pharmaceuticals, Inc. is a clinical-stage biopharmaceutical company. The Company focuses on the discovery and development of therapeutic compounds for autoimmune and inflammatory diseases. The Company's lead compounds are designed to inhibit complement component 3 (C3), the central protein in the complement cascade. The Company’s lead product candidate is APL-2. APL-2 is Phase III clinical trials developed for the treatment of geographic atrophy (GA) and intermediate age-related macular degeneration (AMD) by intravitreal injection, which is an injection into the eye. It is developing APL-2 for the treatment of paroxysmal nocturnal hemoglobinuria (PNH) by subcutaneous injection, which is an injection into the tissue under the skin. The Company is developing APL-9 for intravenous administration in systemic indications.
Company Coordinates stock-summary
Company Details
100 5th Avenue , WALTHAM MA : 02451
stock-summary
Tel: 1 617 97757001 212 6001902
stock-summary
Registrar Details