ScoreWhy is Ionis Pharmaceuticals, Inc. ?
1
Poor Management Efficiency with a low ROE of 0.04%
- The company has been able to generate a Return on Equity (avg) of 0.04% signifying low profitability per unit of shareholders funds
2
Poor long term growth as Operating profit has grown by an annual rate -173.66% of over the last 5 years
3
The company has declared Negative results for the last 3 consecutive quarters
- NET PROFIT(HY) At USD -219.57 MM has Grown at -7,442.94%
- OPERATING CASH FLOW(Y) Lowest at USD -496.44 MM
- DEBT-EQUITY RATIO (HY) Highest at 30.57 %
4
Risky -
- The stock is trading risky as compared to its average historical valuations
- Over the past year, while the stock has generated a return of 33.91%, its profits have risen by 13.2%
Real-Time Research ReportHow much should you sell?
- All quantity irrespective of whether you are making profits or losses
(If sector exposure > 30%, please use optimiser tool to see which are the best stocks to hold in Pharmaceuticals & Biotechnology)
When to re-enter? - We will constantly monitor the company and review our call based on new data
Is Ionis Pharmaceuticals, Inc. for you?
High Risk, High Return
Absolute
Risk Adjusted
Volatility
Ionis Pharmaceuticals, Inc.
33.91%
0.69
53.87%
S&P 500
21.51%
1.63
13.19%
Quality
Management Risk
Growth
Capital StructureQuality key factors
Factor
Value
Sales Growth (5y)
5.29%
EBIT Growth (5y)
-173.66%
EBIT to Interest (avg)
-6.98
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-0.73
Sales to Capital Employed (avg)
0.35
Tax Ratio
1.39%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
0
ROE (avg)
0.04%
ValuationValuation Key Factors 
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
24.37
EV to EBIT
-30.33
EV to EBITDA
-32.25
EV to Capital Employed
70.86
EV to Sales
12.29
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
-233.64%
ROE (Latest)
-79.99%
TechnicalsTechnical key factors
Indicator
Weekly
Monthly
MACD
Mildly Bearish
Bullish
RSI
No Signal
Bearish
Bollinger Bands
Bearish
Mildly Bullish
Moving Averages
Mildly Bullish (Daily)
KST
Mildly Bearish
Bullish
Dow Theory
Mildly Bullish
No Trend
OBV
No Trend
No Trend
Technical Indicator Scale: Bearish, Mildly Bearish, Sideways, Mildly Bullish, Bullish Turned 
Financial Trend2What is working for the Company
NET PROFIT(HY)
Higher at USD -219.57 MM
-13What is not working for the Company
NET PROFIT(HY)
At USD -219.57 MM has Grown at -7,442.94%
OPERATING CASH FLOW(Y)
Lowest at USD -496.44 MM
DEBT-EQUITY RATIO
(HY)
Highest at 30.57 %
Here's what is working for Ionis Pharmaceuticals, Inc.
Net Profit
Higher at USD -219.57 MM
than preceding 12 month period ended Jun 2026MOJO Watch
In the half year the company has already crossed Net Profit of the previous twelve months
Net Profit (USD MM)
Depreciation
Highest at USD 7.64 MM
in the last five periodsMOJO Watch
The expenditure on assets done by the company may have gone into operation
Depreciation (USD MM)
Here's what is not working for Ionis Pharmaceuticals, Inc.
Net Profit
At USD -219.57 MM has Grown at -7,442.94%
Year on Year (YoY)MOJO Watch
Near term Net Profit trend is very negative
Net Profit (USD MM)
Operating Cash Flow
Lowest at USD -496.44 MM
in the last three yearsMOJO Watch
The company's cash revenues from business operations are falling
Operating Cash Flows (USD MM)
Debt-Equity Ratio
Highest at 30.57 %
in the last five Semi-Annual periodsMOJO Watch
The company is borrowing more to fund its operations; it's liquidity situation may be stressed
Debt-Equity Ratio
InfinHub Market Technologies FZ-LLC, Building-2, Unit 112, Dubai Internet City, Dubai, United Arab Emirates
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