Compare Rhythm Pharmaceuticals, Inc. with Similar Stocks
Dashboard
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With a growth in Net Sales of 36.87%, the company declared Very Positive results in Sep 25
- The company has declared positive results for the last 2 consecutive quarters
- OPERATING CASH FLOW(Y) Highest at USD -109.12 MM
- NET PROFIT(HY) Higher at USD -98.84 MM
- RAW MATERIAL COST(Y) Fallen by -1.28% (YoY)
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Risky -
3
Reducing Promoter Confidence
4
Consistent Returns over the last 3 years
Stock DNA
Pharmaceuticals & Biotechnology
USD 6,180 Million (Small Cap)
NA (Loss Making)
NA
0.00%
-1.07
-128.63%
41.53
Revenue and Profits:
Net Sales:
57 Million
(Quarterly Results - Dec 2025)
Net Profit:
-48 Million
Total Returns (Price + Dividend) 
TimePeriod
Price Return
Dividend Return
Total Return
3 Months
-24.63%
0%
-24.63%
6 Months
-12.68%
0%
-12.68%
1 Year
57.52%
0%
57.52%
2 Years
108.68%
0%
108.68%
3 Years
400.71%
0%
400.71%
4 Years
629.48%
0%
629.48%
5 Years
288.7%
0%
288.7%
Rhythm Pharmaceuticals, Inc. for the last several years.
Risk Adjusted Returns v/s 
News
No Recent News for the Company
Announcements 
No announcement available
Corporate Actions 
No corporate action available
Quality key factors 
Factor
Value
Sales Growth (5y)
181.04%
EBIT Growth (5y)
-8.88%
EBIT to Interest (avg)
-74.40
Debt to EBITDA (avg)
Negative Net Debt
Net Debt to Equity (avg)
-3.20
Sales to Capital Employed (avg)
0.40
Tax Ratio
0.07%
Dividend Payout Ratio
0
Pledged Shares
0
Institutional Holding
100.00%
ROCE (avg)
0
ROE (avg)
0
Valuation key factors
Factor
Value
P/E Ratio
NA (Loss Making)
Industry P/E
Price to Book Value
41.53
EV to EBIT
-32.33
EV to EBITDA
-32.59
EV to Capital Employed
-558.52
EV to Sales
34.54
PEG Ratio
NA
Dividend Yield
NA
ROCE (Latest)
Negative Capital Employed
ROE (Latest)
-128.63%
Technicals key factors
Indicator
Weekly
Monthly
MACD
Bearish
Mildly Bearish
RSI
Bullish
Bearish
Bollinger Bands
Bearish
Mildly Bullish
Moving Averages
Mildly Bullish (Daily)
KST
Bearish
Mildly Bearish
Dow Theory
Mildly Bearish
Mildly Bearish
OBV
Mildly Bearish
Mildly Bearish
Shareholding Snapshot : Dec 2025
Shareholding Compare (%holding) 
Majority shareholders
Domestic Funds
Domestic Funds
Held in 77 Schemes (42.56%)
Foreign Institutions
Held by 134 Foreign Institutions (14.33%)
Strategic Entities with highest holding
Highest Public shareholder
Quarterly Results Snapshot (Consolidated) - Dec'25 - YoY
Dec'25
Dec'24
Change(%)
Net Sales
57.30
41.80
37.08%
Operating Profit (PBDIT) excl Other Income
-46.80
-40.90
-14.43%
Interest
4.60
5.40
-14.81%
Exceptional Items
-0.10
-0.10
Consolidate Net Profit
-47.50
-43.30
-9.70%
Operating Profit Margin (Excl OI)
-822.00%
-986.30%
16.43%
USD in Million.
Net Sales
YoY Growth in quarter ended Dec 2025 is 37.08% vs 72.73% in Dec 2024
Consolidated Net Profit
YoY Growth in quarter ended Dec 2025 is -9.70% vs -4.09% in Dec 2024
Annual Results Snapshot (Consolidated) - Dec'25
Dec'25
Dec'24
Change(%)
Net Sales
189.80
130.10
45.89%
Operating Profit (PBDIT) excl Other Income
-190.70
-263.90
27.74%
Interest
20.60
20.60
Exceptional Items
-0.90
7.50
-112.00%
Consolidate Net Profit
-196.50
-260.60
24.60%
Operating Profit Margin (Excl OI)
-1,011.90%
-2,040.40%
102.85%
USD in Million.
Net Sales
YoY Growth in year ended Dec 2025 is 45.89% vs 68.09% in Dec 2024
Consolidated Net Profit
YoY Growth in year ended Dec 2025 is 24.60% vs -41.09% in Dec 2024
About Rhythm Pharmaceuticals, Inc. 
Rhythm Pharmaceuticals, Inc.
Pharmaceuticals & Biotechnology
Rhythm Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is focused on the development and commercialization of peptide therapeutics for the treatment of rare genetic deficiencies that result in life-threatening metabolic disorders. The Company’s lead peptide product candidate is setmelanotide, a potent, first-in-class melanocortin-4 receptor, or MC4R, agonist for the treatment of rare genetic disorders of obesity. Setmelanotide serves as replacement therapy for the treatment of melanocortin-4, or MC4, pathway deficiencies. MC4 pathway deficiencies result in the disruption of satiety signals and energy homeostasis in the body, which, in turn, leads to intense feelings of hunger and to obesity. The Company also focused on obesity related to six single gene-related, or monogenic, MC4 pathway deficiencies pro-opiomelanocortin, or POMC, leptin receptor, or LepR, Bardet-Biedl syndrome, Alstrom syndrome, POMC heterozygous, and POMC epigenetic disorders.
Company Coordinates 
Company Details
222 Berkeley St Fl 12 , BOSTON MA : 02116-3733
Registrar Details






